Browsing by Author "Arslan, Fahrettin"

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Citation - WoS: 3
Alternative Approaches To the Spectral Quantitative Resolution of Two-Component Mixture by Wavelet Families
(Soc Chilena Quimica, 2009) Dinc, Erdal; Baleanu, Dumitru; Arslan, Fahrettin; Baleanu, Dumitru; 6981; Matematik; 02.02. Matematik; 02. Fen-Edebiyat Fakültesi; 01. Çankaya Üniversitesi
A new spectral continuous wavelet transform (CWT) methods are proposed for the quantitative analysis of the binary mixtures. The simultaneous spectral resolution of binary mixtures and tablets containing paracetamol (PAR) and chloroxozone (CHL) with overlapping absorption spectra is performed by six wavelet families with no chemical separation procedure. The calibration graphs for the six wavelet families are obtained by the help of the data collected from the CWT-signal amplitudes corresponding to the zero crossing points in the spectral range of 210 nm-310 nm. The validation of each wavelet family is carried out by analyzing various synthetic binary mixtures of the above mentioned drugs. The second derivative spectrophotometry (D2) is used to compare the experimental results provided by the analyzed continuous wavelet families and a good coincidence is reported for the proposed analytical approaches.
Citation - WoS: 2
Citation - Scopus: 2
Experimental Design and Optimization for the Spectral Analysis of Two-Component Mixture
(Chiminform Data S A, 2007) Dinc, Erdal; Baleanu, Dumitru; Arslan, Fahrettin; Baleanu, Dumitru; 56389; Matematik; 02.02. Matematik; 02. Fen-Edebiyat Fakültesi; 01. Çankaya Üniversitesi
A chemometric experimental design was applied to obtain the optimal settings for spectrophotomeric quantitative resolution of two-component mixture containing benazepril hydrochloride (BE) and hydrochlorothiazide (HCT) in tablets. As it is known, the digital parameters for instance divisor concentration and All-interval are very important concepts for the application of the ratio spectra derivative spectrophotometry to the resolution of binary mixture systems. In this manuscript, a three-level full factor design was used to optimize the effects of the divisor concentration and Delta lambda-interval on the quantitative analysis of the above mentioned drugs in samples. Desirable results were obtained: firstly, with the divisor concentrations and Delta lambda-interval, 21.20 mu g/mL and Delta lambda=27.50 nm for BE in the ratio spectra first derivative spectrophotometry, secondly 27.20 mu g/mL and Delta = 5.4 for HCT in the ratio spectra second derivative method Under the above mentioned conditions, both first and second derivative approaches showed good precision, accuracy and linearity in the quantitative analysis of BE and HCT in two different pharmaceutical tablet products.
Citation - WoS: 5
Citation - Scopus: 6
Spectrophotometric Simultaneous Analysis of Two-Component Mixture by Bivariate and Multivariate Calibrations Using the Linear Regression Functions
(Editura Acad Romane, 2008) Dinc, Erdal; Baleanu, Dumitru; Arslan, Fahrettin; Baleanu, Dumitru; 6981; Matematik; 02.02. Matematik; 02. Fen-Edebiyat Fakültesi; 01. Çankaya Üniversitesi
Spectral bivariate calibration (SBC) and spectral multivariate calibration (SMC) approaches based on the linear regression models were applied to the simultaneous determination of chlorzoxazone (CHL) and paracetamol (PAR) in tablets. SBC model was constructed by using four linear regression functions at two-wavelength set (220 and 244 nm) selecting two optimal wavelengths among 25 wavelength points. SMC model for cacti compound was obtained by using of 50 linear regression functions at 25 wavelength points in the spectral range 220-293 nm without selecting any optimal wavelength points. SBC and SMC was validated by using an independent validation set containing CHL-PAR combinations in the linear concentration range. The recovery results were found between 100.6% and 102.6% for both proposed appropaches, therefore we Conclude that a successuful method application was reported. The results obtained in this study clearly indicate that the proposed SBC and SMC approaches are suitable to be used for the quality control and routine analysis of the commercial tablets containing CHL and PAR compounds.