Browsing by Author "Kanbur, Murat"

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Comparative application of wavelet approaches to absorption and ratio spectra for the simultaneous determination of diminazene aceturate and phenazone in veterinary granules for injection
(Govi-Verlag Pharmazeutischer Verlag GMBH, 2005) Baleanu, Dumitru; Kanbur, Murat; Baleanu, Dumitru; 6981; 36107
A comparison of two wavelet approaches, Daubechies and reverse Biorthogonal, is described for the quantitative resolution of a binary mixture of diminazene aceturate (DIMA) and phenazone (PHE) in veterinary granules for injection without any chemical separation. These two approaches were specified as db4 (a = 180) and rbior3.7 (a = 125) respectively, after testing the signal analysis parameters for the overlapping absorption spectra and ratio spectra. In the first step db4 (a = 180) was applied to the original absorbance data vector of DIMA and PHE. In the second step rbio3.7 (a = 125) was applied to the ratio spectra data vectors of DIMA using the divisor PHE. The same approach was also subjected to the ratio spectra of PHE using the divisor DIMA. The db4 (a = 180) and rbior3.7 (a = 125) calibration graphs were constructed using the transformation values obtained in the wavelet domain. In the method validation, the wavelet calibration functions were tested using synthetic mixtures and the standard addition technique. The simultaneous quantitative analysis of DIMA and PHE in the commercial veterinary preparation was achieved by the elaborated methods. The assay results were compared with each other and good agreement was observed
Comparative spectral analysis of veterinary powder product by continuous wavelet and derivative transforms
(Pergamon-elsevier Science Ltd, 2007) Dinc, Erdal; Baleanu, Dumitru; Kanbur, Murat; Baleanu, Dumitru; 6981; 36107
Comparative simultaneous determination of chlortetracycline and benzocaine in the commercial veterinary powder product was carried out by continuous wavelet transform (CWT) and classical derivative transform (or classical derivative spectrophotometry). In this quantitative spectral analysis, two proposed analytical methods do not require any chemical separation process. In the first step, several wavelet families were tested to find an optimal CWT for the overlapping signal processing of the analyzed compounds. Subsequently, we observed that the coiflets (COIF-CWT) method with dilation parameter, a = 400, gives suitable results for this analytical application. For a comparison, the classical derivative spectrophotometry (CDS) approach was also applied to the simultaneous quantitative resolution of the same analytical problem. Calibration functions were obtained by measuring the transform amplitudes corresponding to zero-crossing points for both CWT and CDS methods. The utility of these two analytical approaches were verified by analyzing various synthetic mixtures consisting of chlortetracycline and benzocaine and they were applied to the real samples consisting of veterinary powder formulation. The experimental results obtained from the COIF-CWT approach were statistically compared with those obtained by classical derivative spectrophotometry and successful results were reported. (C) 2006 Elsevier B.V. All rights reserved.
Fractional Wavelet Transform for the Quantitative Spectral Analysis of Two-Component System
(Springer-Verlag Berlin, 2010) Baleanu, Dumitru; Narin, İbrahim; Özdemir, Esra; Dinç, Erdal; Baleanu, Dumitru; 56389
The fractional wavelet transform (FWT) combined with zero crossing technique was applied to the absorption spectra for the quantitative resolution of a binary mixture consisting of trimethoprim and sulfachloropyridazine sodium. The absorption spectra of trimethoprim and sulfachloropyridazine sodium were processed by FWT method. In the following step, the FWT spectra were obtained by plotting the fractional wavelet coefficients versus the wavelength. Classical second derivative method was applied to the fractional wavelet signals in the wavelet domain. A calibration graphs for each substance were obtained by measuring the FWT-amplitudes at an appropriate wavelength corresponding to a zero crossing point in the derivative spectra of the FWT-signals. The amounts of trimethoprim and sulfachloropyridazine sodium in tablets.
Simultaneous determination of chlorotetracycline and benzocaine in bolus by chemometric methods
(Chiminform Data S A, 2007) Baleanu, Dumitru; Kanbur, Murat; Baleanu, Dumitru; 6981; 36107
Two chemometric methods were applied to the simultaneous determination of chlortetracycline (CTC) and benzocaine (BC) in their binary mixture. The methods involve multivariate calibration based on principal least-squares (PCR) and partial least-squares (PLS) regressions. A concentration set consisting of binary mixtures of CTC and BC in 13 different combinations were randomly prepared in 0,011 M HCl. Both multivariate calibration models were constructed by using the relationship between the concentration set and its corresponding absorption data in the spectral region of 200-305 nm, The accuracy and the precision of the methods were validated by analyzing synthetic mixtures containing investigated drugs. The recovery results obtained by applying PCR and PLS calibrations to artificial mixtures were found between 100.2 and 101.0%. Data treatments, regressions and statistical analysis were performed by using the Microsoft EXCEL and PLS toolbox 3.5 in Matlab 7.0 software. Satisfactory results for both artificial and commercial veterinary samples were obtained. The experimental results from two chemometric methods were compared with each other
Spectrophotometric multicomponent determination of tetramethrin, propoxur and piperonyl butoxide in insecticide formulation by principal component regression and partial least squares techniques with continuous wavelet transform
(Spectroscopy Soc Canada, 2004) Baleanu, Dumitru; Baleanu, Dumitru; Kanbur, Murat; 56389
A continuous wavelet transform (CWT) followed by a principal component regression(PCR) and partial least squares (PLS) were applied for the quantitative determination of tetramethrin (TRM), propoxur (PPS) and piperonil butoxide (PPR) in their formulations. Absorbances of the concentration set formed by TRM, PPS and PPR mixtures were measured at 850 points between 220-350 nm with 0.1 nm intervals, and their absorbance values as absorbance data vectors were transferred into the wavelets domain. A CWT was applied to the absorbance data. The resulting CWT-coefficients (x-block) and concentration set (y-block) were used for the construction of CWT-PCR and CWT-PLS calibrations. The combination of both continuous wavelet and chemometrics techniques indicates good results for the determination of insecticide in synthetic mixtures and commercial formulation