Browsing by Author "Ozdemir, Abdil"

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Citation - WoS: 12
Citation - Scopus: 15
Determination of guaifenesin and dextromethorphan in a cough syrup by HPLC with fluorometric detection
(Editura Academiei Romane, 2006) Ozdemir, Abdil; Aksoy, Halil; Dinc, Erdal; Baleanu, Dumitru; Dermis, Saadet; 26096; 6981; 169890; Matematik
A practical high-performance liquid chromatographic method with fluorometric detection for the determination of guaifenesin and dextromethorphan in cough syrup is described. The developed method contains simple, accurate and rapid sample preparation steps for the separation and simultaneous determination of active compounds in samples with existence of other excipients. Amilorid (AM) was used as an internal standard (IS) that has a fluorescence character in the working wavelength region. A good chromatographic separation of two drugs and IS was achieved on a Waters Symmetry(R) C18 Column 5 mu m 4.6 x 250 mm with mobile phase consisting of phosphate buffer (0.2 M, pH=2), acetonitrile and methyl alcohol (v/v, 62:23:15). Eluents were monitored by fluorescence detection at the excitation and emission wavelengths of 277 and 588 nm, respectively. Under the described conditions, the obtained calibration graphs are linear over the concentration range of 0.054.2 and 1.2-2.4 mg/mL for dextromethorphan and guaifenesin, respectively and the regression coefficients were greater than 0.999. The validation study was carried out fulfilling the ICH guidelines in order to prove that the new analytical method meets the fundamental criteria including selectivity, linearity, precision, accuracy and sensitivity.
Citation - WoS: 7
Citation - Scopus: 7
Spectrophotometric determination of acetaminophen and chlorzoxazone in tablets by multivariate calibration techniques
(Chiminform Data S A, 2006) Dinc, Erdal; Ozdemir, Abdil; Onur, Feyyaz; Baleanu, Dumitru; Aksoy, Halil; Yuecesoy, Cem; 6981; 26096; 3512; Matematik
Three multivariate techniques, Inverse Least Squares (ILS), Principal Component Regression (PCR) and Partial Least Squares (PLS) were applied to the spectrophotometric determination of acetaminophen (AC) and chlorzoxazone (CL) in tablets without prior separation. Stock solutions of acetaminophen and chlorzoxazone were prepared in methanol. Standard solutions were obtained by dilution of stocks with 0.1 M HCl. The multivariate calibrations were built up using training set containing both drugs in different concentration ratios and measuring the absorbances at 14 wavelengths with 5-nm intervals over the wavelength-range of 210-310 nm. Chemometric calculations were performed with MATLAB 7.0 software, The proposed techniques were applied to a commercial formulation, which contains 300 mg AC and 250 mg a(n=10). The results were statistically compared with each other, as well as those obtained by the developed HPLC method.
Citation - WoS: 1
Citation - Scopus: 2
Wavelet transform with chemometrics techniques for quantitative multiresolution analysis of a ternary mixture consisting of paracetamol, ascorbic acid and acetylsalicylic acid in effervescent tablets
(Chiminform Data S A, 2006) Dinc, Erdal; Ozdemir, Abdil; Baleanu, Dumitru; Tas, Kenan; 6981; 26096; 4971; Matematik
Quantitative multiresolution analysis of paracetamol (PAR), ascorbic acid (AA) and acetylsalicylic acid (ASP) in pharmaceutical samples was carried out by using simultaneous use of discrete wavelet transformation (DWT) and afterward partial least squares (PLS) and classical least squares (CLS) techniques. The desired concentration was obtained using a set of 20 different calibration samples of PAR, AA, and ASP in different concentration ratio. The absorption spectra in the spectral range of 220-305 nm were recorded and their absorption values were measured at 850 points with intervals of Delta lambda = 0. 1 nm. The obtained DWT-CLS and DWT-PLS calibrations were tested by analysing the independent synthetic mixture containing the above subject compounds. The experimental results showed that DWT-CLS and DWT-PLS techniques are suitable for simultaneous determination of PAR, AA and ASP in samples. The obtained results were compared with those in literature.