Browsing by Author "Pektas, Gozde"

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Citation - WoS: 2
Citation - Scopus: 2
Simultaneous Quantitative Analysis of Clorsulon and Ivermectin in a Veterinary Formulation by Artificial Neural Network
(Chiminform Data S A, 2008) Dinc, Erdal; Baleanu, Dumitru; Pektas, Gozde
Simultaneaous spectrophotometric determination of clorsulon (CLO) and invermectin (IVE) in commercial veterinary formulation was performed by using the artificial neural network (ANN) based on the back propagation algorithm. In order to find the optimal ANN model various topogical networks were tested by using different hidden layers. A logsig input layer, a hidden layer of neurons using the logsig transfer function and an output layer of two neurons with purelin transfer function was found suitable for basic configuration for ANN model. A calibration set consisting of CLO and IVE in calibration set was prepared in the concentration range of 1-23 mu g/mL and 1-14 mu g/mL, repectively. This calibration set contains 36 different synthetic mixtures. A prediction set was prepared in order to evaluate the recovery of the investigated approach ANN chemometric calibration was applied to the simultaneous analysis of CLO and IVE in compounds in a commercial veterinary formulation. The experimental results indicate that the proposed method is appropriate for the routine quality control of the above mentioned active compounds.
Citation - WoS: 9
Citation - Scopus: 10
Spectrophotometric Simultaneous Determination of Levamisole and Triclabendazole in Tablets by Principal Component Regrassion and Partial Least Squares Chemometric Methods
(Chiminform Data S A, 2008) Dinc, Erdal; Baleanu, Dumitru; Pektas, Gozde
Principal component regression (PCR) and partial least squares (PLS) chemometric methods were applied to the simultaneous quantitative analysis of levamisole (LVM) and triclabendazole (TCB) in tablets without using a preliminary separation, even in presence of the overlapping spectra of the above compounds. For both PCR and PLS, a concentration set containing 25 different mixtures of LVM and TCB in the linear concentration range was symmetrically prepared and then the absorbance values of the concentration set were measured at the wavelength set with Delta lambda=0. 1nm in the spectral region of 225-322.3 nm. PCR and PLS calibrations were obtained by applying the PCR and PLS algorithms to the concentration set data (y-block) and their corresponding absorbance data (x-block). The validity of PCR and PLS chemometric methods was performed by using the independent synthetic mixtures and the standard addition technique. Then, these analytical methods were applied to the commercial tablets and a good agreement was obtained between experimental results provided by the application of the PCR and PLS to the synthetic and real samples.