Çankaya GCRIS Standart veritabanının içerik oluşturulması ve kurulumu Research Ecosystems (https://www.researchecosystems.com) tarafından devam etmektedir. Bu süreçte gördüğünüz verilerde eksikler olabilir.
 

Chemometric approach to simultaneous chromatographic determination of paracetamol and chlorzoxazone in tablets and spiked human plasma

dc.contributor.authorDinç, Erdal
dc.contributor.authorÖzdemir, Abdil
dc.contributor.authorAksoy, Halil
dc.contributor.authorBaleanu, Dumitru
dc.contributor.authorID6981tr_TR
dc.contributor.authorID26096tr_TR
dc.date.accessioned2016-03-31T13:13:56Z
dc.date.available2016-03-31T13:13:56Z
dc.date.issued2006
dc.departmentÇankaya Üniversitesi, Fen Edebiyat Fakültesi, Matematik Bilgisayar Bölümüen_US
dc.description.abstractNew chemometric approaches were introduced into the high performance liquid chromatographic (HPLC) determination of chlorzoxazone (CZX) and paracetamol (PAR) in the tablets and spiked human plasma. These chemometric approaches contain the application of classical least squares (CLS), principle component regression (PCR), and partial least squares (PLS) calibrations to the multiwavelength HPLC peak area obtained by plotting the chromatograms at the five wavelengths. The multichromatograms were obtained by using the photodiode array detector at 225 (A), 240 (B), 255 (C), 270 (D), and 285 (E) nm. The algorithms of CLS, PCR, and PLS were applied to the multichromatogram data to construct the HPLC-CLS, HPLC-PCR, and HPLC-PLS calibrations. A mixture of acetonitrile and 0.1 M ammonium carbonate (60:40, v/v) on a Waters Symmetry (R) trademark C18 Column 5 mu m 4.6 x 250 mm at a flow rate of 0.8 mL/min was used as a mobile phase to separate and determine CZX and PAR in samples. Hydrochlorothiazide (IS) was used as an internal standard in this chromatographic separation. The HPLC chemometric calibrations were successfully applied to the quantitative analysis of the investigated drugs in commercial pharmaceutical preparation and spiked human plasma samples with high precision and accuracyen_US
dc.identifier.citationDinç, E...et al. (2006). Chemometric approach to simultaneous chromatographic determination of paracetamol and chlorzoxazone in tablets and spiked human plasma. Journal of Liquid Chromatography & Related Technologies, 29(12), 1803-1822. http://dx.doi.org/10.1080/10826070600717023en_US
dc.identifier.doi10.1080/10826070600717023
dc.identifier.endpage1822en_US
dc.identifier.issn1082-6076
dc.identifier.issue12en_US
dc.identifier.startpage1803en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12416/802
dc.identifier.volume29en_US
dc.language.isoenen_US
dc.publisherTaylor&Francis Incen_US
dc.relation.ispartofJournal of Liquid Chromatography & Related Technologiesen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHPLC-Chemometric Methodsen_US
dc.subjectSpiked Human Plasmaen_US
dc.subjectTabletsen_US
dc.subjectChlorzoxazoneen_US
dc.subjectParacetamolen_US
dc.titleChemometric approach to simultaneous chromatographic determination of paracetamol and chlorzoxazone in tablets and spiked human plasmatr_TR
dc.titleChemometric Approach To Simultaneous Chromatographic Determination of Paracetamol and Chlorzoxazone in Tablets and Spiked Human Plasmaen_US
dc.typeArticleen_US
dspace.entity.typePublication

Files

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: