Stability analysis and numerical simulations of spatiotemporal HIV CD4+T cell model with drug therapy

Abstract

In this study, an extended spatiotemporal model of a human immunodeficiency virus (HIV) CD4+ T cell with a drug therapy effect is proposed for the numerical investigation. The stability analysis of equilibrium points is carried out for temporal and spatiotemporal cases where stability regions in the space of parameters for each case are acquired. Three numerical techniques are used for the numerical simulations of the proposed HIV reaction-diffusion system. These techniques are the backward Euler, Crank-Nicolson, and a proposed structure preserving an implicit technique. The proposed numerical method sustains all the important characteristics of the proposed HIV model such as positivity of the solution and stability of equilibria, whereas the other two methods have failed to do so. We also prove that the proposed technique is positive, consistent, and Von Neumann stable. The effect of different values for the parameters is investigated through numerical simulations by using the proposed method. The stability of the proposed model of the HIV CD4+ T cell with the drug therapy effect is also analyzed.