Akın, Şeniz R. KuşhanGarcia, Caterina BartomeuWebster, Thomas J.2022-02-112022-02-112021Akın, Şeniz R. Kuşhan; Garcia, Caterina Bartomeu; Webster, Thomas J. (2021). "A comparative study of silicon nitride and SiAlON ceramics against E. coli", Ceramics International, Vol. 47, no. 2, pp. 1837-1843.0272-8842https://hdl.handle.net/20.500.12416/5009In recent decades, due to some limitations from alumina (Al2O3) and zirconia (ZrO2), silicon nitride (Si3N4) has been investigated as a novel bioceramic material, mainly in situations where a bone replacement is required. Si3N4 ceramics and its derivative form, SiAlON, possess advantages in orthopedics due to their mechanical properties and biologically acceptable chemistry, which accelerates bone repair. However, biological applica- tions require additional properties, enabling stronger chemical bonding to the surrounding tissue for better fixation and the prevention of bacteria biofilm formation. Therefore, two commercial Si3N4 and SiAlON ceramics were investigated in this study and compared to each other according to their material properties (like wetting angles and surface chemistry) and their antibacterial behaviors using E. coli. Results provided evidence of a 15% reduction in E. coli colonization after just 24 h on Si3N4 compared to SiAlON which is impressive considering no antibiotics were used. Further, a mechanism of action is provided. In this manner, this study provides evidence that Si3N4 should be further studied for a wide range of antibacterial orthopedic, or other suitable biomaterial applications.eninfo:eu-repo/semantics/openAccessSilicon NitrideSi3N4SiAlONBioceramicsAntibacterialArticle4721837184310.1016/j.ceramint.2020.09.012