Yildirim, E.Yıldırım, EnderÖzgür, E.Külah, H.Makine Mühendisliği06.06. Makine Mühendisliği06. Mühendislik Fakültesi01. Çankaya Üniversitesi2025-09-232025-09-232012Yıldırım, Ender; Özgür, E.; Külah, H.; "A Droplet Based Multi-Drug Screening System Controlled With Electrostatic Microvalves", Proceedings of the 16th International Conference On Miniaturized Systems for Chemistry and Life Sciences, Microtas 2012, pp. 959-961, (2012).9780979806452https://hdl.handle.net/20.500.12416/15638'Fed. Pharmaceut. Manufacturers' Assoc. of JAPAN (FPMAJ)'; Centre National de la Recherche Scientifique (CNRS); Enplas Corporation; et al.; Musashi Engineering, Inc.; Univ. of Tokyo, Institute of Industrial Science (IIS)This paper presents a droplet-based drug effect analysis system utilizing electrostatically-actuated normallyclosed microvalves to screen the effect of multiple drugs on a single type of cell. Proposed system minimizes the need for off-chip equipment by utilizing parylene based electrostatic microvalves. Prototypes of the system were fabricated and tested using colored DI water and 3 μm diameter micro beads, emulating drugs and cells respectively. During the tests, micro beads could be successfully entrapped in 137 pl droplets. Tests carried out with yeast cells also yielded successful encapsulation of the cells. It was shown that, switching between the drugs could be achieved by applying 200 V dc to operate the microvalves.eninfo:eu-repo/semantics/closedAccessElectrostaticMicrovalveMulti-Drug ScreeningParyleneConference Object2-s2.0-84901798447