Dinç, EBaleanu, DumitruBaleanu, D2020-04-152020-04-152002Dinç, E.; Baleanu, Dumitru, "Spectrophotometric quantitative determination of cilazapril and hydrochlorothiazide in tablets by chemometric methods" Journal Of Pharmaceutical And Biomedical Analysis, Vol.30, No.3, pp.715-723, (2002).0731-7085https://doi.org/10.1016/S0731-7085(02)00359-XFour chemometric methods were applied to simultaneous determination of cilazapril and hydrochlorothiazide in tablets. Classical least-square (CLS), inverse least-square (ILS), principal component regression (PCR) and partial least-squares (PLS) methods do not need any priori graphical treatment of the overlapping spectra of two drugs in a mixture. For all chemometric calibrations a concentration set of the random mixture consisting of the two drugs in 0.1 M HCl and methanol (1:1) was prepared. The absorbance data in the UV-Vis spectra were measured for the 15 wavelength points (from 222 to 276 nm) in the spectral region 210-290 nm considering the intervals of Deltalambda = 4 nm. The calibration of the investigated methods involves only absorbance and concentration data matrices. The developed calibrations were tested for the synthetic mixtures consisting of two drugs and using the Maple V software the chemometric, calculations were performed. The results of the methods were compared each other as well as with HPLC method and a good agreement was found. (C) 2002 Elsevier Science B.V. All rights reserved.eninfo:eu-repo/semantics/closedAccessChemometric MethodsQuantitative DeterminationCilazaprilHydrochlorothiazideTabletsConference Object30371572310.1016/S0731-7085(02)00359-X2-s2.0-0037201710WOS:00017882640003512367697Q2Q2