Browsing by Author "Dinc, Erdal"

Now showing 1 - 14 of 14

A new approach to the characterization of the nano-surface structure by using factor analysis
(Elsevier, 2012) Dinc, Erdal; Baleanu, Dumitru; Baleanu, Dumitru; Solak, Ali Osman; Eksi, Haslet; Guzel, Remziye; 6981; 234363; 192756
The study provides a new approach to explore the existence of a nanostructure on the benzoic acid-modified glassy carbon electrode (BA-GC) system by applying factor analysis with varimax rotation of factors. The infrared spectra (IR) spectra of the bare glassy carbon electrodes (GC) and the BA-GC electrode systems with benzoic acid-nanofilm (BA-FILM) were obtained by using 10 different surface modification experiments. The IR data of the bare GC, BA-GC and BA-FILM were categorized into three series corresponding to the GC, BA-GC and BA-FILM. The factor analysis method was separately applied to each group to extract the factor loadings. By making use of these loadings, the rotated factor loadings corresponding to the first two factors were computed to estimate the relationship among and within groups. The results provided by the factor analysis method indicate the existence of the BA-FILM on the BA modified glassy carbon electrode. (C) 2011 Elsevier B.V. All rights reserved.
Analysis of the Nano-Surface of A Modified Glassy Carbon Electrode By Pseudo Phase Plane Method
(Amer Scientific Publishers, 2011) Tenreiro Machado, J. A.; Baleanu, Dumitru; Baleanu, Dumitru; Dinc, Erdal; Solak, Ali Osman; Eksi, Haslet; Guzel, Remziye; 56389
This paper presents the Pseudo phase plane (PPP) method for detecting the existence of a nanofilm on the nitroazobenzene-modified glassy carbon electrode (NAB-GC) system. This modified electrode systems and nitroazobenze-nanofilnn were prepared by the electrochemical reduction of diazonium salt of NAB at the glassy carbon electrodes (GCE) in nonaqueous media. The IR spectra of the bare glassy carbon electrodes (GCE), the NAB-GC electrode system and the organic NAB film were recorded. The IR data of the bare GC, NAB-GC and NAB film were categorized into five series consisting of FILM1, GC-NAB1, GC1; FILM2, GC-NAB2, GC2; FILM3, GC-NAB3, GC3 and FILM4, GC-NAB4, GC4 respectively. The PPP approach was applied to each group of the data of unmodified and modified electrode systems with nanofilm. The results provided by PPP method show the existence of the NAB film on the modified GC electrode.
Analysis of UV spectral bands using multidimensional scaling
(Springer London Ltd, 2015) Tenreiro Machado, J. A.; Baleanu, Dumitru; Dinc, Erdal; Baleanu, Dumitru; 6981
This study describes the change of the ultraviolet spectral bands starting from 0.1 to 5.0 nm slit width in the spectral range of 200-400 nm. The analysis of the spectral bands is carried out by using the multidimensional scaling (MDS) approach to reach the latent spectral background. This approach indicates that 0.1 nm slit width gives higher-order noise together with better spectral details. Thus, 5.0 nm slit width possesses the higher peak amplitude and lower-order noise together with poor spectral details. In the above-mentioned conditions, the main problem is to find the relationship between the spectral band properties and the slit width. For this aim, the MDS tool is to used recognize the hidden information of the ultraviolet spectra of sildenafil citrate by using a Shimadzu UV-VIS 2550, which is in the world the best double monochromator instrument. In this study, the proposed mathematical approach gives the rich findings for the efficient use of the spectrophotometer in the qualitative and quantitative studies.
Application of continuous wavelet transform to the analysis of the modulus of the fractional Fourier transform bands for resolving two component mixture
(Springer London Ltd, 2015) Dinc, Erdal; Baleanu, Dumitru; Duarte, Fernando B.; Machado, J. A. Tenreiro; Baleanu, Dumitru; 6981
In this paper, the fractional Fourier transform (FrFT) is applied to the spectral bands of two component mixture containing oxfendazole and oxyclozanide to provide the multicomponent quantitative prediction of the related substances. With this aim in mind, the modulus of FrFT spectral bands are processed by the continuous Mexican Hat family of wavelets, being denoted by MEXH-CWT-MOFrFT. Four modulus sets are obtained for the parameter of the FrFT going from 0.6 up to 0.9 in order to compare their effects upon the spectral and quantitative resolutions. Four linear regression plots for each substance were obtained by measuring the MEXH-CWT-MOFrFT amplitudes in the application of the MEXH family to the modulus of the FrFT. This new combined powerful tool is validated by analyzing the artificial samples of the related drugs, and it is applied to the quality control of the commercial veterinary samples.
Characterization approach to modified glassy carbon electrode-nanofilm system within multidimensional scaling
(Amer Scientific Publishers, 2011) Tenreiro Machado, J. A.; Baleanu, Dumitru; Baleanu, Dumitru; Dinc, Erdal; Solak, All Osman; Eksi, Haslet; Guzel, Remziye; 6981; 192756
The aim of this work is to characterize the nanofilm consisting of the benzoic acid-modified glassy carbon (GC) electrode system through multidimensional scaling space analysis. The surface modification is based on the electrochemical reaction between the GC electrode and benzoic acid-diazonium salt (BA-DAS). As a result, the nonofilms regarding the benzoic acid-glassy carbon (BA-GC) electrode surface was obtained. For the analysis of the naonfilm of BC-GC electrode system, the IR spectra of the modified BA-GC electrode surface, GC surface and BA-DAS were recorded in the spectral range of 599.84 - 3996.34 [cm(-1)]. The IR data vectors of the above three forms were processed by the using the multidimensional scaling space approach to demonstrate the existence of a nanofilm on the modified BA-GC electrode system. Two- and three-dimensional MDS profiles obtained by application of multidimensional scaling approach to the data sets {CG1, ... ,CG10}, {BA-GC1, ... ,BA-GC10} and {FILM1, ... ,FILM10} allow a good recognition of the nanofilm on the modified glassy carbon (GC) electrode system.
Comparative spectral analysis of veterinary powder product by continuous wavelet and derivative transforms
(Pergamon-elsevier Science Ltd, 2007) Dinc, Erdal; Baleanu, Dumitru; Kanbur, Murat; Baleanu, Dumitru; 6981; 36107
Comparative simultaneous determination of chlortetracycline and benzocaine in the commercial veterinary powder product was carried out by continuous wavelet transform (CWT) and classical derivative transform (or classical derivative spectrophotometry). In this quantitative spectral analysis, two proposed analytical methods do not require any chemical separation process. In the first step, several wavelet families were tested to find an optimal CWT for the overlapping signal processing of the analyzed compounds. Subsequently, we observed that the coiflets (COIF-CWT) method with dilation parameter, a = 400, gives suitable results for this analytical application. For a comparison, the classical derivative spectrophotometry (CDS) approach was also applied to the simultaneous quantitative resolution of the same analytical problem. Calibration functions were obtained by measuring the transform amplitudes corresponding to zero-crossing points for both CWT and CDS methods. The utility of these two analytical approaches were verified by analyzing various synthetic mixtures consisting of chlortetracycline and benzocaine and they were applied to the real samples consisting of veterinary powder formulation. The experimental results obtained from the COIF-CWT approach were statistically compared with those obtained by classical derivative spectrophotometry and successful results were reported. (C) 2006 Elsevier B.V. All rights reserved.
Continuous wavelet and derivative transforms for the simultaneous quantitative analysis and dissolution test of levodopa-benserazide tablets
(Elsevier, 2007) Dinc, Erdal; Baleanu, Dumitru; Kaya, Sueha; Doganay, Tanver; Baleanu, Dumitru; 6981; 133597
Simultaneous analyses and dissolution tests of levodopa-benserazide tablets were carried out by continuous wavelet transform (CWT) and classic derivative spectrophotometry (DS) without using any chemical separation step. The developed two spectrophotometric resolutions are based on the transformation of the original UV spectra. The original absorption spectra of levodopa and benserazide in the concentration range of 1-80 mu g/mL and 5-240 mu g/mL in USP simulated gastric juice were registered in the spectral range of 250-310 nm, respectively. Various wavelet families and different spectrophotometric derivative orders were tested to find the optimal signal processing for obtaining desirable calibration graphs and reliable determinations of the investigated drugs. Under the optimized conditions of the methods, symlets wavelet family using a = 128 with sixth order (SYM6-CWT) and the first derivative transform with Delta lambda = 10 nm were identified as optimal signal processing methods for the determinations and dissolution tests. The calibration functions for each drug were obtained by measuring the values of the CWT and derivative amplitudes. The validation of the developed methods was confirmed by analyzing various synthetic mixtures of the investigated drugs. Mean recovery values were found between 99.1% and 104.7% for DS and 100% and 102.9% for CWT, respectively for determination of BEN and LEV in synthetic mixtures. Each developed approaches were successfully applied to the simultaneous determination and dissolution test of levodopa and benserazide in their commercial tablets and a good agreement was observed. (c) 2007 Elsevier B.V. All rights reserved.
Continuous wavelet transform and chemometric methods for quantitative resolution of a binary mixture of quinapril and hydrochlorothiazide in tablets
(Soc Brasileira Quimica, 2007) Dinc, Erdal; Baleanu, Dumitru; Baleanu, Dumitru; 56389
Quantitative resolution of the quinapril and hydrochlorothiazide mixture in tablets was achieved by using continuous wavelet transform and chemometric methods. In the case of the continuous wavelet transform, various continuous wavelet families were tested in order to find the optimum point of the wavelet signal processing technique. The Mexican hat wavelet function was reported to be the optimal one. The Mexican hat wavelet function was applied to the absorption spectra of quinapril and hydrochlorothiazide in the spectral range of 200-320 nm for standard series of drugs in the concentration range of 4.0-20.0 mu g mL(-1) quinapril and 2.5-12.5 mu g mL(-1) hydrochlorothiazide. The calibration functions for quinapril at 230.6 nm and for hydrochlorothiazide at 271.1 nm were calculated based on the relationship between the measurements of continuous wavelet signals and their concentrations. According to the chemometric approach, partial least squares and principal component regression calibrations were constructed by a training set of 21 mixtures, containing two drugs and their corresponding absorbance data, in the wavelength range of 205-290 nm. All proposed methods were validated by the independent analysis of the synthetic mixtures and by the standard addition technique. The application of the methods indicated that their selectivity and the sensitivity were satisfactory. The investigated methods were successfully applied to tablet analysis.
Factor Analysis for the Characterization of the Nano-Surface of the Nitroazobenzene-Modified Glassy Carbon Electrode
(Amer Scientific Publishers, 2012) Dinc, Erdal; Baleanu, Dumitru; Baleanu, Dumitru; Solak, Ali Osman; Eksi, Haslet; Guzel, Remziye; 56389
Factor analysis with orthogonal varimax rotation was applied to determine the existence of a nano-structure on the nitroazobenze-modified glassy carbon electrode (NAB-GC) system. The NAB-GC electrode systems and benzoic acid-nanofilm (NAB-FILM) were obtained by using the electrochemical surface modification experiments. The IR spectra of the bare glassy carbon electrodes (GC), the NAB-GC electrode system and NAB-FILM were recorded. The IR data of the bare GC, BA-GC and BA-FILM were categorized into five series consisting of FILM1, GC-NAB1, GC1; FILM2, GC-NAB2, GC2; FILM3, GC-NAB3, GC3; FILM4, GC-NAB4, GC4; FILM5, GC-NAB5, GC5, respectively. The factor loadings were extracted by making use of the factor analysis approach applied to each group. The orthogonal varimax rotation technique was used to obtain the rotated factor loadings corresponding to the first two factors. After the estimation of the relationship among and within groups, the results predict the existence of the NAB-FILM on the NAB modified glassy carbon electrodes.
Fractional and continuous wavelet transforms for the simultaneous spectral analysis of a binary mixture system
(Elsevier, 2011) Dinc, Erdal; Baleanu, Dumitru; Buker, Eda; Baleanu, Dumitru; 6981
A combined application of the fractional wavelet transform-continuous wavelet transform to the quantitative resolution of the overlapping signals of olmesartan modoxomil and hydrochlorothiazide in a binary mixture was presented. In this work the recorded absorption signals of two compounds in the range 4-12 mu g/mL olmesartan and 2-10 mu g/mL hydrochlorothiazide were processed by the fractional transform approach and with the continuous wavelet transform, respectively. The proposed combined complex signal analysis method was validated by analyzing the synthetic binary mixtures of the related compound. By analyzing the statistical parameters we conclude that the new approach is suitable to be used for the quality control of the commercial samples of compounds. (C) 2011 Published by Elsevier B.V.
Fractional wavelet analysis of the composite signals of two-component mixture by multivariate spectral calibration
(Sage Publications Ltd, 2007) Dinc, Erdal; Baleanu, Dumitru; Baleanu, Dumitru; Tas, Kenan; 6981
The fractional wavelet transform is a new mathematical tool for signal and image analysis. In this study, fractional wavelet analysis of the composite signals of the components in a binary mixture was investigated. In the quantitative evaluation of hydrochlorothiazide and cilazapril, partial least squares calibration was applied to the fractional wavelet coefficients after optimization of the experimental conditions. The validation of the partial least squares approach was tested by analyzing various synthetic mixtures consisting of active compounds of interest. Hydrochlorothiazide and cilazapril in real samples were analyzed using partial least squares calibration based on the fractional wavelet coefficients without a prior chemical separation procedure. This combined method is a potential new chemometric approach and is suitable for quantitative analysis of the components in samples.
Fractional wavelet transform-continous wavelet transform for the quantification of melatonin and its photodegradation product
(Taylor & Francis inc, 2012) Dinc, Erdal; Baleanu, Dumitru; Ragno, Gaetano; Baleanu, Dumitru; De Luca, Michele; Ioele, Giuseppina; 6981
In this study a new signal processing approach based on the simultaneous use of fractional and continuous wavelet transforms was suggested for the quantitative estimation of melatonin and its photodegradation products in their samples. The UV spectra of melatonin and its degradation product were recorded between 200.0 and 455.0 nm and processed by the fractional wavelet algorithm. The obtained fractional wavelet coefficients were treated by biorthogonal and symplets wavelet families in order to quantify melatonic and its photodegradation product, respectively. The calibration graphs for the related main compound and its degradation product were obtained by measuring the fractional-continuous wavelet amplitudes at 432.0 nm for melatonin and 435.0 nm for its degradation product. The validity and applicability of the double transforms based on fractional and continuous wavelets were confirmed by analyzing various synthetic mixtures of melatonin and its degradation product. Successful results were reported in the application of the improved fractional-continuous wavelet transform to the sample analysis.
Fractional-Continuous Wavelet Transforms and Ultra-Performance Liquid Chromatography for the Multicomponent Analysis of A Ternary Mixture Containing Thiamine, Pyridoxine, and Lidocaine in Ampules
(Oxford Univ Press inc, 2012) Dinc, Erdal; Baleanu, Dumitru; Baleanu, Dumitru; 56389
New chemometric approaches based on the application of partial least squares (PLS) and principal component regression (PCR) algorithms with fractional wavelet transform (FWT) and continuous wavelet transform (CWT) are proposed for the spectrophotometric multicomponent determination of thiamine hydrochloride (B-1), pyridoxine hydrochloride (B-6), and lidocaine hydrochloride (LID) in ampules without any separation step. In this study PLS and PCR techniques were applied to the raw spectral data, FWT-coefficients, and FWT-CWT-coefficients. These calibration models were labeled as Raw-PLS and Raw-PCR, FWT-PLS and FWT-PCR, and FWT-CWT-PLS and FWT-CWT-PCR, respectively. A new ultra-performance liquid chromatographic (UPLC) method was developed for the comparison of the results obtained by applying the chemometric calibration methods. Chromatographic separation and determination of B-1, B-6, and LID in ampules were performed on an Acquity UPLC (R) BEH C18 column (50 x 2.1 mm id, 1.7 mu m particle size) using gradient elution with a mobile phase consisting of methanol and 0.01 M HCl at a constant flow rate of 0.6 mL/min. These combined chemometric calibrations and UPLC were validated by analyzing various ternary mixtures, B-1, B-6, and LID. The proposed chemometric approaches (signal processing-multivariate calibrations) and UPLC method were applied to the quantitative multicomponent analysis of marketed ampules containing the vitamins B1 and B-6 with LID.
New Spectral Approaches To the Simultaneous Quantitative Resolution of A Combined Veterinary Formulation By Ann and Pca-Ann Methods
(Walter de Gruyter & Co, 2011) Dinc, Erdal; Baleanu, Dumitru; Baleanu, Dumitru; Sen Koktas, Nigar; 56389
The simultaneous spectral prediction of levamisole (LEV) and triclabendazole (TRI) in combined veterinary formulation was performed by the new chemometric methods, artificial neural network (ANN) and principal component analysis-artificial neural network (PCA-ANN). Despite the overlapping spectra of LEV and TRI in the same wavelength region, the proposed methods do not use any separation procedure for the analysis of the related compounds. Good precision and accuracy were observed for the applications of the proposed artificial neural network models to an independent binary mixture set consisting of the active compounds. These methods were successfully applied for the chemometric quantitation of a veterinary formulation of LEV and TRI.