Browsing by Author "Dinc, Erdal"

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Citation - WoS: 3
Alternative Approaches To the Spectral Quantitative Resolution of Two-Component Mixture by Wavelet Families
(Soc Chilena Quimica, 2009) Dinc, Erdal; Baleanu, Dumitru; Arslan, Fahrettin; Baleanu, Dumitru; Matematik
A new spectral continuous wavelet transform (CWT) methods are proposed for the quantitative analysis of the binary mixtures. The simultaneous spectral resolution of binary mixtures and tablets containing paracetamol (PAR) and chloroxozone (CHL) with overlapping absorption spectra is performed by six wavelet families with no chemical separation procedure. The calibration graphs for the six wavelet families are obtained by the help of the data collected from the CWT-signal amplitudes corresponding to the zero crossing points in the spectral range of 210 nm-310 nm. The validation of each wavelet family is carried out by analyzing various synthetic binary mixtures of the above mentioned drugs. The second derivative spectrophotometry (D2) is used to compare the experimental results provided by the analyzed continuous wavelet families and a good coincidence is reported for the proposed analytical approaches.
Citation - WoS: 15
Citation - Scopus: 14
Analysis of a Nanofilm of the Mercaptophenyl Diazonium Modified Gold Electrode Within New Statistical Parameters
(Amer Scientific Publishers, 2010) Baleanu, Dumitru; Dinc, Erdal; Ustundag, Zafer; Solak, Ali Osman; Kargin, Roman V.; Nigmatullin, Raoul R.
The main aim of this study is to characterize the nanosurface of the mercaptophenyl diazonium modified gold (Au) surface by a new statistical approach. In this study the gold electrode surfaces were self-assembled in ethyl alcohol by 1.0 mM mercaptophenyl diazonium. FT-IR spectra of the surface modifier molecules in both solid and nanofilm of mercaptophenyl diazonium (MCP-Au) forms were recorded in the spectral range of 600-4,000 cm(-1). The FT-IR spectra of solid mercaptophenyl diazonium tetrafluoroborate salt were obtained by using KBr pellets. The above FT-IR spectra of both bare Au and its nanofilm of mercaptophenyl diazonium were processed by new statistical approach to reach optimal smoothing trend for the characterization of the modified electrode surface consisting of the nanofilm of gold-mercaptophenyl diazonium. In the frame of new statistical approach all measured spectra have been 'read' in terms of a set of universal statistical parameters. These new parameters help to establish the statistical proximity of the smoothed spectra compared and give a possibility to classify the measured spectra in accordance with new set of statistical and robust quantitative values. Besides, there is a possibility to receive the relative fluctuations and the smoothed spectra of the second order. So, thanks to new approach we do not loose any measured information: the smoothed spectra and accompanied them noise (relative fluctuations) can be analyzed separately for detection of possible influence of predominant external factors that can be essential for this type of measurements.
Citation - WoS: 9
Citation - Scopus: 10
Analysis of the Effect of Potential Cycles on the Reflective Infrared Signals of Nitro Groups in Nanofilms: Application of the Fractional Moments Statistics
(Wiley-v C H verlag Gmbh, 2010) Alekhin, Alexander P.; Baleanu, Dumitru; Dinc, Erdal; Ustundag, Zafer; Eksi, Haslet; Solak, Ali Osman; Nigmatulin, Raoul R.
The effect of the potential cycles on the reflective IR signals of nitro-groups in nanofilms was studied for the statistical characterization of nitrobenzene (NB) and nitroazobenzene (NAB)-modified glassy carbon (GC) surfaces. Both NB and NAB nanofilms were obtained by the electrochemical reduction of the diazonium tetrafluoroborate salts in acetonitrile using cyclic voltammetry (CV). The modified surfaces were denoted as GC-(NB)(n) and GC-(NAB)(n), respectively, where n indicates the number of CV cycles performed during modification. Reflective IR signals of the normalized NB and NAB nanofilms and GC were used for the quantitative evaluation of the effect of the potential cycles on the reflective IR signals of nitro-groups in nanofilms. The detection and quantitative 'reading' of the influence of number of CV cycles were realized in the frame of a new error controllable approach that was applied for analysis of all available set of data. This approach includes in itself the following basic steps: (a) the procedure of the division (normalization) on the GC spectra, (b) the comparison of the smoothed spectra for their statistical proximity in the frame of the statistics of the fractional moments, (c) extraction of possible calibration parameters for possible calibration of the normalized spectra with respect to the number of CV cycles. These three basic steps are becoming effective for detection of the influence of some external factors. In our case it is important to detect the influence of the factor n characterizing CV cycles.
Citation - WoS: 1
Citation - Scopus: 1
Analysis of the Nano-Surface of a Modified Glassy Carbon Electrode by Pseudo Phase Plane Method
(Amer Scientific Publishers, 2011) Baleanu, Dumitru; Dinc, Erdal; Solak, Ali Osman; Eksi, Haslet; Guzel, Remziye; Tenreiro Machado, J. A.
This paper presents the Pseudo phase plane (PPP) method for detecting the existence of a nanofilm on the nitroazobenzene-modified glassy carbon electrode (NAB-GC) system. This modified electrode systems and nitroazobenze-nanofilnn were prepared by the electrochemical reduction of diazonium salt of NAB at the glassy carbon electrodes (GCE) in nonaqueous media. The IR spectra of the bare glassy carbon electrodes (GCE), the NAB-GC electrode system and the organic NAB film were recorded. The IR data of the bare GC, NAB-GC and NAB film were categorized into five series consisting of FILM1, GC-NAB1, GC1; FILM2, GC-NAB2, GC2; FILM3, GC-NAB3, GC3 and FILM4, GC-NAB4, GC4 respectively. The PPP approach was applied to each group of the data of unmodified and modified electrode systems with nanofilm. The results provided by PPP method show the existence of the NAB film on the modified GC electrode.
Citation - WoS: 4
Citation - Scopus: 6
Analysis of Uv Spectral Bands Using Multidimensional Scaling
(Springer London Ltd, 2015) Dinc, Erdal; Baleanu, Dumitru; Tenreiro Machado, J. A.
This study describes the change of the ultraviolet spectral bands starting from 0.1 to 5.0 nm slit width in the spectral range of 200-400 nm. The analysis of the spectral bands is carried out by using the multidimensional scaling (MDS) approach to reach the latent spectral background. This approach indicates that 0.1 nm slit width gives higher-order noise together with better spectral details. Thus, 5.0 nm slit width possesses the higher peak amplitude and lower-order noise together with poor spectral details. In the above-mentioned conditions, the main problem is to find the relationship between the spectral band properties and the slit width. For this aim, the MDS tool is to used recognize the hidden information of the ultraviolet spectra of sildenafil citrate by using a Shimadzu UV-VIS 2550, which is in the world the best double monochromator instrument. In this study, the proposed mathematical approach gives the rich findings for the efficient use of the spectrophotometer in the qualitative and quantitative studies.
Citation - WoS: 3
Citation - Scopus: 4
Application of Continuous Wavelet Transform To the Analysis of the Modulus of the Fractional Fourier Transform Bands for Resolving Two Component Mixture
(Springer London Ltd, 2015) Duarte, Fernando B.; Machado, J. A. Tenreiro; Baleanu, Dumitru; Dinc, Erdal
In this paper, the fractional Fourier transform (FrFT) is applied to the spectral bands of two component mixture containing oxfendazole and oxyclozanide to provide the multicomponent quantitative prediction of the related substances. With this aim in mind, the modulus of FrFT spectral bands are processed by the continuous Mexican Hat family of wavelets, being denoted by MEXH-CWT-MOFrFT. Four modulus sets are obtained for the parameter of the FrFT going from 0.6 up to 0.9 in order to compare their effects upon the spectral and quantitative resolutions. Four linear regression plots for each substance were obtained by measuring the MEXH-CWT-MOFrFT amplitudes in the application of the MEXH family to the modulus of the FrFT. This new combined powerful tool is validated by analyzing the artificial samples of the related drugs, and it is applied to the quality control of the commercial veterinary samples.
Citation - WoS: 15
Citation - Scopus: 16
Application of Haar and Mexican Hat Wavelets To Double Divisor-Ratio Spectra for the Multicomponent Determination of Ascorbic Acid, Acetylsalicylic Acid and Paracetamol in Effervescent Tablets
(Soc Brasileira Quimica, 2008) Baleanu, Dumitru; Dinc, Erdal
Simultaneous determination of ascorbic acid (AA), acetylsalicylic acid (ASP) and paracetamol (PAR) in their synthetic mixtures and effervescent tablets were performed by Haar and Mexican continuous wavelet transforms (HAAR-CWT and MEXH-CWT, respectively) together with double divisor technique. The signal processing methods are based on the application of HAAR-CWT and MEXH-CWT to the double divisor-ratio spectra (DDRS). These spectra were obtained by dividing the absorption spectra of pure compound and its ternary mixtures by a double-divisor or standard spectrum corresponding to a mixture of two compounds in ternary mixture. A combined use of HAAR-CWT and MEXH-CWT with double divisor-ratio spectra (DDRS) was denoted by DDRS-HAAR CWT and DDRS-MEXH CWT. To check the ability or applicability of the developed DDRS-CWT methods, the double divisor-ratio spectra-derivative spectrophotometric (DDRS-DS) method, as a comparison method, was applied to the above mentioned samples containing AA, ASP and PAR and satisfactory results were obtained.
Citation - WoS: 2
Citation - Scopus: 3
An Application of Principal Component Analysis - Artificial Neural Network for the Simultaneous Quantitative Analysis of a Binary Mixture System
(Chiminform Data S A, 2009) Dinc, Erdal; Baleanu, Dumitru; Sen Koktas, Nigar; Köktaş, Nigar; Baleanu, Dumitru; Matematik
Artificial neural networks (ANNs) based on the use of principal components and the original absorbance data were proposed for the simultaneous quantitative analysis of amlodipine (AML) and atorvastatin (ATO) in tablets. A concentration set of mixtures containing ATO and AML in different concentration composition between 0.0-20.0 mu g/mL was prepared in methanol. The measured absorbance data matrix for the concentration data set was obtained and the principal components were extracted. In the next step five principal components were selected as an input data for the artificial neural network. This combined approach was named principal components-artificial neural network (PCA-ANN). The same problem was solved by using the application of the artificial neural network to the original absorbance data matrix. This approach was denoted as ANN. The classical ANN approach was used as a comparison method. Both PCA-ANN and ANN methods were tested by analyzing various synthetic mixtures corresponding to the validation set of AML and ATO compounds. The proposed methods were successfully applied to the quantitative analysis of the commercial tablets and a coincidence was reported between the proposed methods.
Citation - WoS: 2
Citation - Scopus: 2
Applications of Mexican Hat Wavelet Function To Binary Mixture Analysis
(Chiminform Data S A, 2008) Uestuendag, Oezguer; Baleanu, Dumitru; Dinc, Erdal; Baleanu, Dumitru; Matematik
The simultaneous determination of pyridoxine hydrochloride (B6) and isoniazide (INH) in tablets was performed by using the Mexican hat wavelet function (MEXH). The absorption spectra of B6, INH and their samples were recorded in the spectral range of 200-330 nm. Linear regression functions for B6 and INH in the linear concentration range of 5-45 mu g/mL were obtained by measuring the transformed signals at 253.5 nm corresponding to the zero-crossing point for INH and at 270.6 nm corresponding to the zero-points for B6, respectively. The validation of MEXH method was performed by using the synthetic mixtures. The percent mean recoveries and their relative standard deviations were found as 98.7% and 2.06 for B6 and 98.9% and 1.89 for INH in the synthetic mixture analysis. The MEXH method was applied to the real samples and a good sensitivity and selectivity was reported. The MEXH method was sucessfully compared with classical derivative method.
Citation - WoS: 9
Citation - Scopus: 14
Characterization Approach To Modified Glassy Carbon Electrode-Nanofilm System Within Multidimensional Scaling
(Amer Scientific Publishers, 2011) Baleanu, Dumitru; Dinc, Erdal; Solak, All Osman; Eksi, Haslet; Guzel, Remziye; Tenreiro Machado, J. A.
The aim of this work is to characterize the nanofilm consisting of the benzoic acid-modified glassy carbon (GC) electrode system through multidimensional scaling space analysis. The surface modification is based on the electrochemical reaction between the GC electrode and benzoic acid-diazonium salt (BA-DAS). As a result, the nonofilms regarding the benzoic acid-glassy carbon (BA-GC) electrode surface was obtained. For the analysis of the naonfilm of BC-GC electrode system, the IR spectra of the modified BA-GC electrode surface, GC surface and BA-DAS were recorded in the spectral range of 599.84 - 3996.34 [cm(-1)]. The IR data vectors of the above three forms were processed by the using the multidimensional scaling space approach to demonstrate the existence of a nanofilm on the modified BA-GC electrode system. Two- and three-dimensional MDS profiles obtained by application of multidimensional scaling approach to the data sets {CG1, ... ,CG10}, {BA-GC1, ... ,BA-GC10} and {FILM1, ... ,FILM10} allow a good recognition of the nanofilm on the modified glassy carbon (GC) electrode system.
Citation - WoS: 18
Citation - Scopus: 18
Characterization of a Benzoic Acid Modified Glassy Carbon Electrode Expressed Quantitatively by New Statistical Parameters
(Elsevier, 2009) Baleanu, Dumitru; Dinc, Erdal; Solak, Ali Osman; Nigmatullin, Raoul R.
The main aim of this study is to characterize the nanosurface of the benzoic acid modified glassy carbon (GC) electrode by using a new statistical approach. In this study, the electrode surfaces were modified by cyclic voltametry in the potential range of +0.4 and -0.8 V at a scan rate 200 mV s(-1) for four cycles versus Ag/Ag+ electrode in acetonitrile containing 0.1 M tetrabutylammonium tetraflouroborate (TBATFB). FT-IR spectra of the surface modifier molecules in both solid (GC and nanofilm (GC-benzoic acid)) forms were recorded in the spectral range 600-4000 cm(-1). The FT-IR spectra of p-aminobenzoic acid were obtained by using KBr pellets. The above FT-IR spectra of both GC and its nanofilm with benzoic acid were processed by new statistical approach to reach optimal smoothing trend for the characterization of the modified electrode surface consisting of the nanofilm of GC-benzoic acid. In the frame of new statistical approach all measured spectra have been 'read' in terms of a set of universal statistical parameters. (C) 2008 Elsevier B.V. All rights reserved.
Citation - WoS: 3
Citation - Scopus: 2
Chemometric Simultaneous Determination of Atorvastatin and Amlodipine in Tablets by Pcr and Pls Calibrations
(Chiminform Data S A, 2009) Dinc, Erdal; Baleanu, Dumitru; Baleanu, Dumitru; Matematik
Principal component regression (PCR) and partial least squares (PLS) chemometric methods were applied to the simultaneous quantitative analysis of atorvastatin (ATO) and amlodipine (AML) in tablets without using a preliminary separation and even in presence of the overlapping spectra of the above mentioned compounds. For both PCR and PLS methods, a concentration set containing 17 different mixtures of ATO and AML in the linear concentration range of 0.0-20.0 mg/mL for both compounds was randomly prepared and then the absorbance values of the concentration set were measured at the 551 points-wavelength set with interval of Delta lambda=0.1 nm from 215 nm to 2 70 nm in the spectral range of 202320 nm. PCR and PLS calibrations were obtained by applying the PCR and PLS algorithms to the concentration set data (y-block) and their corresponding absorbance data (x-block). The validity of PCR and PLS chemometric methods was performed by using the independent synthetic mixtures and the standard addition technique. These analytical methods were applied to the commercial tablets and a good agreement was obtained between experimental results provided by the application of the PCR and PLS to the synthetic and real samples.
Citation - WoS: 5
Citation - Scopus: 9
Combined Application of Continuous Wavelet Transform-Zero Crossing Technique in the Simultaneous Spectrophotometric Determination of Perindopril and Indapamid in Tablets
(Soc Brasileira Quimica, 2009) Pektas, Goezde; Baleanu, Dumitru; Dinc, Erdal; Baleanu, Dumitru; Matematik
Signal processing methods based on the combined use of the continuous wavelet transform (CWT) and zero-crossing technique were applied to the simultaneous spectrophotometric determination of perindopril (PER) and indapamide (IND) in tablets. These signal processing methods do not require any priory separation step. Initially, various wavelet families were tested to identify the optimum signal processing giving the best recovery results. From this procedure, the Haar and Biorthogonal 1.5 continuous wavelet transform (HAAR-CWT and BIOR 1.5-CWT, respectively) were found suitable for the analysis of the related compounds. After transformation of the absorbance vectors by using HAAR-CWT and BIOR 1.5-CWT, the CWT-coefficients were drawn as a graph versus wavelength and then the HAAR-CWT and BIOR 1.5-CWT spectra were obtained. Calibration graphs for PER and IND were obtained by measuring the CWT amplitudes at 231.1 and 291.0 rim in the HAAR-CWT spectra and at 228.5 and 246.8 nm in BIOR 1.5-CWT spectra. respectively. In order to compare the performance of HAAR-CWT and BIOR 1.5-CWT approaches, derivative spectrophotometric (DS) method and HPLC as comparison methods, were applied to the PER-IND samples. In this DS method, first derivative absorbance values at 221.6 for PER and 282.7 nm for IND were used to obtain the calibration graphs. The validation of the CWT and DS signal processing methods was carried out by using the recovery study and standard addition technique. In the following step, these methods were Successfully applied to the commercial tablets containing PER and IND compounds and good accuracy and precision were reported for the experimental results obtained by all proposed signal processing methods.
Citation - WoS: 24
Citation - Scopus: 26
Comparative Spectral Analysis of Veterinary Powder Product by Continuous Wavelet and Derivative Transforms
(Pergamon-elsevier Science Ltd, 2007) Kanbur, Murat; Baleanu, Dumitru; Dinc, Erdal
Comparative simultaneous determination of chlortetracycline and benzocaine in the commercial veterinary powder product was carried out by continuous wavelet transform (CWT) and classical derivative transform (or classical derivative spectrophotometry). In this quantitative spectral analysis, two proposed analytical methods do not require any chemical separation process. In the first step, several wavelet families were tested to find an optimal CWT for the overlapping signal processing of the analyzed compounds. Subsequently, we observed that the coiflets (COIF-CWT) method with dilation parameter, a = 400, gives suitable results for this analytical application. For a comparison, the classical derivative spectrophotometry (CDS) approach was also applied to the simultaneous quantitative resolution of the same analytical problem. Calibration functions were obtained by measuring the transform amplitudes corresponding to zero-crossing points for both CWT and CDS methods. The utility of these two analytical approaches were verified by analyzing various synthetic mixtures consisting of chlortetracycline and benzocaine and they were applied to the real samples consisting of veterinary powder formulation. The experimental results obtained from the COIF-CWT approach were statistically compared with those obtained by classical derivative spectrophotometry and successful results were reported. (C) 2006 Elsevier B.V. All rights reserved.
Citation - WoS: 48
Citation - Scopus: 54
Continuous Wavelet and Derivative Transforms for the Simultaneous Quantitative Analysis and Dissolution Test of Levodopa-Benserazide Tablets
(Elsevier, 2007) Kaya, Sueha; Doganay, Tanver; Baleanu, Dumitru; Dinc, Erdal
Simultaneous analyses and dissolution tests of levodopa-benserazide tablets were carried out by continuous wavelet transform (CWT) and classic derivative spectrophotometry (DS) without using any chemical separation step. The developed two spectrophotometric resolutions are based on the transformation of the original UV spectra. The original absorption spectra of levodopa and benserazide in the concentration range of 1-80 mu g/mL and 5-240 mu g/mL in USP simulated gastric juice were registered in the spectral range of 250-310 nm, respectively. Various wavelet families and different spectrophotometric derivative orders were tested to find the optimal signal processing for obtaining desirable calibration graphs and reliable determinations of the investigated drugs. Under the optimized conditions of the methods, symlets wavelet family using a = 128 with sixth order (SYM6-CWT) and the first derivative transform with Delta lambda = 10 nm were identified as optimal signal processing methods for the determinations and dissolution tests. The calibration functions for each drug were obtained by measuring the values of the CWT and derivative amplitudes. The validation of the developed methods was confirmed by analyzing various synthetic mixtures of the investigated drugs. Mean recovery values were found between 99.1% and 104.7% for DS and 100% and 102.9% for CWT, respectively for determination of BEN and LEV in synthetic mixtures. Each developed approaches were successfully applied to the simultaneous determination and dissolution test of levodopa and benserazide in their commercial tablets and a good agreement was observed. (c) 2007 Elsevier B.V. All rights reserved.
Citation - WoS: 13
Citation - Scopus: 18
Continuous Wavelet Transform and Chemometric Methods for Quantitative Resolution of a Binary Mixture of Quinapril and Hydrochlorothiazide in Tablets
(Soc Brasileira Quimica, 2007) Baleanu, Dumitru; Dinc, Erdal
Quantitative resolution of the quinapril and hydrochlorothiazide mixture in tablets was achieved by using continuous wavelet transform and chemometric methods. In the case of the continuous wavelet transform, various continuous wavelet families were tested in order to find the optimum point of the wavelet signal processing technique. The Mexican hat wavelet function was reported to be the optimal one. The Mexican hat wavelet function was applied to the absorption spectra of quinapril and hydrochlorothiazide in the spectral range of 200-320 nm for standard series of drugs in the concentration range of 4.0-20.0 mu g mL(-1) quinapril and 2.5-12.5 mu g mL(-1) hydrochlorothiazide. The calibration functions for quinapril at 230.6 nm and for hydrochlorothiazide at 271.1 nm were calculated based on the relationship between the measurements of continuous wavelet signals and their concentrations. According to the chemometric approach, partial least squares and principal component regression calibrations were constructed by a training set of 21 mixtures, containing two drugs and their corresponding absorbance data, in the wavelength range of 205-290 nm. All proposed methods were validated by the independent analysis of the synthetic mixtures and by the standard addition technique. The application of the methods indicated that their selectivity and the sensitivity were satisfactory. The investigated methods were successfully applied to tablet analysis.
Citation - WoS: 11
Citation - Scopus: 14
Continuous Wavelet Transform and Derivative Spectrophotometry for the Quantitative Spectral Resolution of a Mixture Containing Levamizole and Triclabendazole in Veterinary Tablets
(Freund Publishing House Ltd, 2009) Pektas, Goezde; Baleanu, Dumitru; Dinc, Erdal
Continuous wavelet transform (CWT) and derivative spectrophotometry (DS) were used for the quantitative determination of levamizole (LE) and triclabendazole (TR) in the commercial veterinary tablets without any priory separation step. Among all available wavelet families, biorthogonal continuous wavelet family (BIOR 3.9-CWT) with dilation parameter a=132 was found to be the one which provides the optimal signal processing tool for the reliable recovery results. BIOR 3.9-CWT was applied to the absorption data consisting of 1024 data points in the spectral range of 224-326.3 nm and CWT coefficients were plotted versus wavelength to obtain BIOR 3.9-CWT spectra. Calibration graphs for LE and TR compounds were calculated by considering the CWT amplitudes. DS approach was used for checking the results obtained by BIOR 3.9-CWT method. For DS method, third derivative spectrophotometry was found to be suitable for the determination of the related compounds. The performance of both analytical methods was verified by analyzing several synthetic mixtures containing LE and TR and by using the standard addition method. Good accuracy, precision and selectivity were reported. CWT and DS were successfully applied to the analysis of the commercial veterinary tablets.
Citation - WoS: 14
Citation - Scopus: 23
Continuous Wavelet Transform Applied To the Overlapping Absorption Signals and Their Ratio Signals for the Quantitative Resolution of Mixture of Oxfendazole and Oxyclozanide in Bolus
(Food & Drug Adminstration, 2007) Dinc, Erdal; Baleanu, Dumitru; Baleanu, Dumitru; Matematik
Continuous wavelet transform (CWT) was applied to the overlapping absorption signals and their ratio signals for the quantitative resolution of mixture of oxfendazole (OXF) and oxyclozanide (OXY) in bolus without using any pre-chemical treatment. Mexican hat function (MEXH) and Morlet (MORL) continuous wavelet transforms (MEXH-CWT and MORL-CWT) for signal treatments were found to be suitable among the wavelet families. In the first step MEXH-CWT together with zero crossing technique is directly applied to the overlapping absorption spectra of OXF and OXY drugs and their calibration graphs were obtained by measuring the MEXH-CWT amplitudes at 328.7 nm for OXY and at 309.3 nm for OXF in the wavelet domain of 255-365 nm. In the second step MORL-CWT is used for finding the significant peak resolution of the ratio spectra of OXY and OXF respectively. The maxima and minima of CWT amplitudes and peak-to-peak and zero-crossing techniques were used for the calibration graphs. The method performances of CWT-zero crossing and ratio spectra-CWT techniques were validated by analyzing the synthetic mixtures and by applying the standard addition technique, and successfully accuracy, precision and reproducibility results were reported.
Citation - WoS: 8
Citation - Scopus: 8
Continuous Wavelet Transform Applied To the Quantitative Analysis of a Binary Mixture
(Revista Chimie Srl, 2009) Dinc, Erdal; Baleanu, Dumitru; Baleanu, Dumitru; Matematik
Signal processing methods, continuous wavelet transform (CWT) methods, were proposed for the simultaneous spectral determination of ampicillin sodium (AS) and sulbactam sodium (SS) in their synthetic binary mixtures and pharmaceutical preparations. Firstly, the ratio spectra were obtained by dividing the absorption spectra of a pure compound and its binary mixture by a standard spectrum of one of the compounds in binary mixture. Secondly, the ratio spectra of AS, SS and their samples were processed by the Mexican hat-CWT and Symtles3-CWT (MEX-CWT and SYM3-CWT, respectively). hi this application, the MEX and SYM3 among wavelet families were found to be optimal to obtain the highest spectral recoveries. Calibration graphs of AS and SS in the linear concentration range of 10-70 mu g/mL and 10-55 mu g/mL were obtained by measuring the amplitudes of the transformed ratio signals, respectively. Percent mean recoveries obtained by application of the CWT methods to the synthetic mixtures were found between 99.1 % and 103.6 %. Both SYM3-CWT and MEX-CWT methods were applied to the real samples containing two active compounds and successful results were obtained.
Citation - WoS: 7
Citation - Scopus: 7
Continuous Wavelet Transform Applied To the Simultaneous Spectrophotometric Determination of Valsartan and Amlodipine in Tablets
(Chiminform Data S A, 2010) Dinc, Erdal; Baleanu, Dumitru; Baleanu, Dumitru; Matematik
A new signal procesing approach based on continuous wavelet transform (CWT) was proposed for the simultaneous spcetroptometric determination of valsartan and amlodipine in tablets without making use of any chemical separation procedure. After the CWT method was applied to the analyzed spectra, the results were plotted in wavelet domain. Several CWT families were tested and Daubechie10 (db10-CWT) and DMeyer (dmey-CWT) were found suitable for the determination of VAL and AML. The procedure of the selection of CWT family was based on the recovery results of signal analysis. Calibration graphs obtained by the linear regression analysis were performed by measuring the CWT amplitudes at 258.5 and 263.3 nm for VAL by using dmey-CWT and db10-CWT and at 265.7 and 270 nm for AML by using dmey-CWT and db10-CWT respectively. Linear calibration ranges were considered as 2-42 mu g/mL for VAL and 2-32 mu g/mL for AML respectively. The validation treatments for the proposed CWT methods were performed by analyzing various synthetic mixtures and by using the standard addition technique. Successful determination results were obtained by applying db10-CWT and dmey-CWT methods to the tablet analysis.