Browsing by Author "Külah, H."

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Citation - Scopus: 1
A Droplet Based Multi-Drug Screening System Controlled With Electrostatic Microvalves
(Chemical and Biological Microsystems Society, 2012) Yildirim, E.; Yıldırım, Ender; Özgür, E.; Külah, H.; 31835; Makine Mühendisliği
This paper presents a droplet-based drug effect analysis system utilizing electrostatically-actuated normallyclosed microvalves to screen the effect of multiple drugs on a single type of cell. Proposed system minimizes the need for off-chip equipment by utilizing parylene based electrostatic microvalves. Prototypes of the system were fabricated and tested using colored DI water and 3 μm diameter micro beads, emulating drugs and cells respectively. During the tests, micro beads could be successfully entrapped in 137 pl droplets. Tests carried out with yeast cells also yielded successful encapsulation of the cells. It was shown that, switching between the drugs could be achieved by applying 200 V dc to operate the microvalves.
Citation - Scopus: 0
Dielectrophoretic Detection of Imatinib Resistance in K562 Cells Using a Lab-On System
(Chemical and Biological Microsystems Society, 2019) Yalçın, Y.D.; Töral, T.B.; Sukas, S.; Yıldırım, E.; Zorlu, Ö.; Gündüz, U.; Külah, H.
This study presents label-free detection of imatinib resistance in K562 cells via integrated dielectrophoretic detection and impedimetric counting on a lab-on-a-chip system. Two impedimetric counting units were placed upstream and downstream of dielectrophoretic detection unit to obtain differential cell count and consequently the trapping ratio. The trapping ratio up to 57% was achieved for imatinib resistant (~60-fold) K562 cells, while it was minimized to 20% for wild type K562 cells. © 2019 CBMS-0001.
Citation - Scopus: 0
Droplet based cell screening system integrated with CMOS image sensor and android-based application
(Chemical and Biological Microsystems Society, 2020) Özkan, M.D.; Aslan, M.K.; Atik, A.C.; Özgür, E.; Yıldırım, E.; Külah, H.
This paper presents a droplet based single cell screening concept, where the cells encapsulated in microdroplets are monitored by integrating a commercial CMOS image sensor to the microfluidic chip. The images acquired through the image sensor are streamed and processed via an Android-based application on smartphone. This integrated system offers microscope-free screening of cells within the droplets based on their shapes. © 17CBMS-0001.