Dielectrophoretic Detection of Imatinib Resistance in K562 Cells Using a Lab-On System
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Date
2019
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Chemical and Biological Microsystems Society
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Abstract
This study presents label-free detection of imatinib resistance in K562 cells via integrated dielectrophoretic detection and impedimetric counting on a lab-on-a-chip system. Two impedimetric counting units were placed upstream and downstream of dielectrophoretic detection unit to obtain differential cell count and consequently the trapping ratio. The trapping ratio up to 57% was achieved for imatinib resistant (~60-fold) K562 cells, while it was minimized to 20% for wild type K562 cells. © 2019 CBMS-0001.
Description
Chemical and Biological Microsystems Society (CBMS)
Keywords
Dielectrophoresis, Imatinib Resistance, Impedimetric Counting, Lab-On-A-Chip, Label-Free Detection
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23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 -- 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 -- 27 October 2019 through 31 October 2019 -- Basel -- 163704
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1358
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1359
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