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Malzeme Bilimi ve Mühendisliği Bölümü

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Browsing Malzeme Bilimi ve Mühendisliği Bölümü by Subject "Antibacterial"

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    Citation Count: Kuşhan Akın, Şeniz R.; Dölekçekiç, Emrah; Webster, Thomas J. (2021). "Antibacterial behavior of oxynitride glasses as a glassy grain boundary phase for silicon nitride-based ceramics", Internatİonal Journal of Applied Glass Science, Vol. 12, No. 3, pp. 328-336.
    Antibacterial behavior of oxynitride glasses as a glassy grain boundary phase for silicon nitride-based ceramics
    (2021) Kuşhan Akın, Şeniz R.; Dölekçekiç, Emrah; Webster, Thomas J.; 224219
    Silicon nitride-based ceramics have provided significant advantages due to their high chemical resistance, high elastic modulus, and combination of hardness and fracture toughness (depending on self-reinforcement). Over the past two decades, a significant amount of interest has been generated for the bio-applications of these materials. However, the effect of the grain boundary phase on such applications is still not very well understood. In this study, the effect of different cations on biological (such as antibacterial and cytocompatibilty) and material properties (like wetting angles and isoelectric points [IEP]) of oxynitride glasses, mimicking the grain boundary phase in Si3N4 and SiAlON ceramics, were investigated. Results revealed that the antibacterial behavior and mammalian cell viability were inversely correlated in glasses with rare-earth cation additions. Ca was the best cation when the two properties (bacterial response and cell proliferation) were considered together, and, thus should be further studied for a wide range of applications.
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    Citation Count: Akın, Şeniz R. Kuşhan; Dölekçekiç, Emrah; Webster, Thomas J. (2021). "Effect of nitrogen on the antibacterial behavior of oxynitride glasses", Ceramics International, Vol. 47, No. 13, pp. 18213-18217.
    Effect of nitrogen on the antibacterial behavior of oxynitride glasses
    (2021) Akın, Şeniz R. Kuşhan; Dölekçekiç, Emrah; Webster, Thomas J.; 22421
    The main drawback of bioglasses is their restricted use in load bearing applications and the consequent need to develop stronger glassy materials. This has led to the consideration of oxynitride glasses for numerous biomedical applications. This paper investigated two different types of glasses at a constant cationic ratio, with and without nitrogen (a N containing and a N-free glass composition) to better understand the effect of N on the biological properties of glasses. The results revealed that the addition of N increased the glass transition temperature, isoelectric point (IEP) and slightly increased wettability. Moreover, compared to N including glass, N-free glass exhibited better anti-bacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), two key bacteria that infect implants. In summary, these in vitro results indicated that amine functional groups existing in N containing glasses which are missing in N-free glasses, caused a slight difference in wetting behavior and a more obvious change in isoelectric point and in bacterial response. N-free glasses exhibited better inhibitory results both against E. coli and S. aureus compared to N including glass suggesting that oxygen rich glasses should be further studied for their novel antibacterial properties.