Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12416/8651
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Article Citation - WoS: 2Citation - Scopus: 5Quantitative Analysis of a Mixture Containing Ampicillin Sodium and Sulbactam Sodium by Ratio Spectra-First and Ratio Spectra-Second Derivative Methods(Chiminform Data S A, 2007) Dinc, Erdal; Baleanu, Dumitru; Baleanu, Dumitru; MatematikTwo signal processing approaches, ratio spectra- first and ratio spectra-second derivative, are proposed for quantitative analysis of a mixture containing ampicillin sodium (AP) and sulbactam sodium (SB) in two different commercial pharmaceutical preparations for injection. These new methods have the advantage that no chemical priory separation step is required In this investigation, the UV-absorption spectra of the analyzed drugs and their samples are recorded in the spectral range of 210-340 nm. The ratio spectra are obtained by dividing the absorbance values of SB to standard divisor (50 mu g/mL) AP and by dividing the absorbance values of AP to standard divisor (40 mu g/mL) of SB. Both first and second derivatives of the obtained ratio spectra are calculated by using Delta lambda=8 nm intervals for both AP and SB. In order to minimize the deformations of the first derivative graph, we used a smooth function for Delta lambda=8. The appropriate graphs of second derivative method are obtained after multiplication with two scaling factors, namely 50 for AP and 40 for SB, but without any smoothing process. Calibration graphs are obtained by measuring the amplitudes at 233.5 nm for AP and 252.2 rim, 275.0 nm and 288.2 nm of the first derivative of the ratio spectra, and by measuring the amplitudes at 246.9 nm for AP and 248.4 nm, 274.2 nm, 285.4 nm and 300.0 nm for SB of the second derivative of the ratio spectra, respectively. The proposed approaches are validated by analyzing the synthetic mixtures and are used to determine AP and 0 in their pharmaceutical preparations.Article Citation - WoS: 4Citation - Scopus: 6Analysis of Uv Spectral Bands Using Multidimensional Scaling(Springer London Ltd, 2015) Dinc, Erdal; Baleanu, Dumitru; Tenreiro Machado, J. A.; Machado, J. A. TenreiroThis study describes the change of the ultraviolet spectral bands starting from 0.1 to 5.0 nm slit width in the spectral range of 200-400 nm. The analysis of the spectral bands is carried out by using the multidimensional scaling (MDS) approach to reach the latent spectral background. This approach indicates that 0.1 nm slit width gives higher-order noise together with better spectral details. Thus, 5.0 nm slit width possesses the higher peak amplitude and lower-order noise together with poor spectral details. In the above-mentioned conditions, the main problem is to find the relationship between the spectral band properties and the slit width. For this aim, the MDS tool is to used recognize the hidden information of the ultraviolet spectra of sildenafil citrate by using a Shimadzu UV-VIS 2550, which is in the world the best double monochromator instrument. In this study, the proposed mathematical approach gives the rich findings for the efficient use of the spectrophotometer in the qualitative and quantitative studies.Article Citation - WoS: 3Citation - Scopus: 4Application of Continuous Wavelet Transform To the Analysis of the Modulus of the Fractional Fourier Transform Bands for Resolving Two Component Mixture(Springer London Ltd, 2015) Duarte, Fernando B.; Machado, J. A. Tenreiro; Baleanu, Dumitru; Dinc, ErdalIn this paper, the fractional Fourier transform (FrFT) is applied to the spectral bands of two component mixture containing oxfendazole and oxyclozanide to provide the multicomponent quantitative prediction of the related substances. With this aim in mind, the modulus of FrFT spectral bands are processed by the continuous Mexican Hat family of wavelets, being denoted by MEXH-CWT-MOFrFT. Four modulus sets are obtained for the parameter of the FrFT going from 0.6 up to 0.9 in order to compare their effects upon the spectral and quantitative resolutions. Four linear regression plots for each substance were obtained by measuring the MEXH-CWT-MOFrFT amplitudes in the application of the MEXH family to the modulus of the FrFT. This new combined powerful tool is validated by analyzing the artificial samples of the related drugs, and it is applied to the quality control of the commercial veterinary samples.Article Citation - WoS: 13Citation - Scopus: 13Ratio Spectra-Continuous Wavelet Transform and Ratio Spectra-Derivative Spectrophotometry for the Quantitative Analysis of Effervescent Tablets of Vitamin C and Aspirin(Revista Chimie Srl, 2008) Baleanu, Dumitru; Dinc, ErdalSimultaneous spectrophotometric analysis of tablets and binary mixtures containing vitamin C (VC) and aspirin (ASP) with overlapping spectra was performed by ratio spectra-continuous wavelet transform (RS-CWT) and ratio spectra-derivative spectrophotometry (RS-DS). In the application of RS-CWT and RS-DS to the simultaneous analysis of VC and ASP no separation step was considered. The basis of RS-CWT and RS-DS approaches is the transformation and the derivation of the ratio spectra of the related compounds and their samples. Calibration graphs in the linear concentration range 4-20 mu g/mL for both compounds were obtained by measuring the CWT and first derivative amplitudes at 260.8 nm for VC and 234.6 nm for ASP in the BIOR-CWT spectra and at 256.0 nm for VC and 230.7 nm for ASP in the first derivative of ratio spectra, respectively. Both methods were tested by using the synthetic mixtures and standard addition technique, and were applied to the simultaneous determination of VC and ASP in commercial effervescent tablets and a good coincidence was reported for experimental results obtained by the proposed RS-CWT and RS-DS.Conference Object Citation - WoS: 4Citation - Scopus: 4Fractional Wavelet Analysis of the Composite Signals of Two-Component Mixture by Multivariate Spectral Calibration(Sage Publications Ltd, 2007) Baleanu, Dumitru; Tas, Kenan; Dinc, ErdalThe fractional wavelet transform is a new mathematical tool for signal and image analysis. In this study, fractional wavelet analysis of the composite signals of the components in a binary mixture was investigated. In the quantitative evaluation of hydrochlorothiazide and cilazapril, partial least squares calibration was applied to the fractional wavelet coefficients after optimization of the experimental conditions. The validation of the partial least squares approach was tested by analyzing various synthetic mixtures consisting of active compounds of interest. Hydrochlorothiazide and cilazapril in real samples were analyzed using partial least squares calibration based on the fractional wavelet coefficients without a prior chemical separation procedure. This combined method is a potential new chemometric approach and is suitable for quantitative analysis of the components in samples.