Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12416/8651
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Article Citation - WoS: 2Citation - Scopus: 3An Application of Principal Component Analysis - Artificial Neural Network for the Simultaneous Quantitative Analysis of a Binary Mixture System(Chiminform Data S A, 2009) Dinc, Erdal; Baleanu, Dumitru; Sen Koktas, Nigar; Köktaş, Nigar; Baleanu, Dumitru; Kökias, Nigar Şen; MatematikArtificial neural networks (ANNs) based on the use of principal components and the original absorbance data were proposed for the simultaneous quantitative analysis of amlodipine (AML) and atorvastatin (ATO) in tablets. A concentration set of mixtures containing ATO and AML in different concentration composition between 0.0-20.0 mu g/mL was prepared in methanol. The measured absorbance data matrix for the concentration data set was obtained and the principal components were extracted. In the next step five principal components were selected as an input data for the artificial neural network. This combined approach was named principal components-artificial neural network (PCA-ANN). The same problem was solved by using the application of the artificial neural network to the original absorbance data matrix. This approach was denoted as ANN. The classical ANN approach was used as a comparison method. Both PCA-ANN and ANN methods were tested by analyzing various synthetic mixtures corresponding to the validation set of AML and ATO compounds. The proposed methods were successfully applied to the quantitative analysis of the commercial tablets and a coincidence was reported between the proposed methods.Article Citation - WoS: 3Citation - Scopus: 2Chemometric Simultaneous Determination of Atorvastatin and Amlodipine in Tablets by Pcr and Pls Calibrations(Chiminform Data S A, 2009) Dinc, Erdal; Baleanu, Dumitru; Baleanu, Dumitru; MatematikPrincipal component regression (PCR) and partial least squares (PLS) chemometric methods were applied to the simultaneous quantitative analysis of atorvastatin (ATO) and amlodipine (AML) in tablets without using a preliminary separation and even in presence of the overlapping spectra of the above mentioned compounds. For both PCR and PLS methods, a concentration set containing 17 different mixtures of ATO and AML in the linear concentration range of 0.0-20.0 mg/mL for both compounds was randomly prepared and then the absorbance values of the concentration set were measured at the 551 points-wavelength set with interval of Delta lambda=0.1 nm from 215 nm to 2 70 nm in the spectral range of 202320 nm. PCR and PLS calibrations were obtained by applying the PCR and PLS algorithms to the concentration set data (y-block) and their corresponding absorbance data (x-block). The validity of PCR and PLS chemometric methods was performed by using the independent synthetic mixtures and the standard addition technique. These analytical methods were applied to the commercial tablets and a good agreement was obtained between experimental results provided by the application of the PCR and PLS to the synthetic and real samples.Article Citation - WoS: 7Citation - Scopus: 7Continuous Wavelet Transform Applied To the Simultaneous Spectrophotometric Determination of Valsartan and Amlodipine in Tablets(Chiminform Data S A, 2010) Dinc, Erdal; Baleanu, Dumitru; Baleanu, Dumitru; MatematikA new signal procesing approach based on continuous wavelet transform (CWT) was proposed for the simultaneous spcetroptometric determination of valsartan and amlodipine in tablets without making use of any chemical separation procedure. After the CWT method was applied to the analyzed spectra, the results were plotted in wavelet domain. Several CWT families were tested and Daubechie10 (db10-CWT) and DMeyer (dmey-CWT) were found suitable for the determination of VAL and AML. The procedure of the selection of CWT family was based on the recovery results of signal analysis. Calibration graphs obtained by the linear regression analysis were performed by measuring the CWT amplitudes at 258.5 and 263.3 nm for VAL by using dmey-CWT and db10-CWT and at 265.7 and 270 nm for AML by using dmey-CWT and db10-CWT respectively. Linear calibration ranges were considered as 2-42 mu g/mL for VAL and 2-32 mu g/mL for AML respectively. The validation treatments for the proposed CWT methods were performed by analyzing various synthetic mixtures and by using the standard addition technique. Successful determination results were obtained by applying db10-CWT and dmey-CWT methods to the tablet analysis.