WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12416/8653
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Article Citation - WoS: 19Citation - Scopus: 18A New Application of Chemometric Techniques To Hplc Data for the Simultaneous Analysis of a Two-Component Mixture(Taylor & Francis inc, 2005) Üstündag, Ö; Özdemir, A; Baleanu, D; Dinç, EA new chemometric approach using high performance liquid chromatography (HPLC) with photodiode array (PDA) detection was developed and applied to the simultaneous determination of enalapril maleate (EA) and hydrochlorothiazide (HCT) in tablets. Chernometric calibration techniques, classical least squares (CLS), principle component regression (PCR), and partial least squares (PLS) were subjected to the peak area at multiwavelength PDA detector responses. The combination of HPLC and chernometric calibration techniques was called HPLC-CLS, HPLC-PCR, and HPLC-PLS. For comparison purposes, the HPLC method called classical HPLC method was used for the confirmation of the results obtained from combined HPLC-chemometric calibration techniques. A good chromatographic separation between two drugs and internal standard (IS) was achieved using a Waters Symmetry (R) C 18 Column 5 mu m 4.6 x 250 mm and a mobile phase consisting of 0.2M acetate buffer and acetonitrile (v/v, 60:40). The multiwavelength PDA detection was done at 230 (A), 240 (B), 250 (C), 250 (D), 240 (E) nm wavelengths, and peak area was recorded for the concentration set in the mobile phase. Three HPLC-chemometric calibrations and a classical-HPLC method were tested by analyzing the synthetic mixture of EA and HCT in the presence of losartan potassium (IS). The proposed methods were applied to real samples containing the present two drugs. The obtained results were statistically compared with each other.Article Citation - WoS: 7Citation - Scopus: 9The Importance and Impact of Fossil and Renewable Energy Sources in Turkey on Business and the Economy(Taylor & Francis inc, 2015) Gokmen, A.; Temiz, D.Turkey is rapidly growing in terms of both its economy and its population. In parallel, its demand for energy is increasing fast. Energy is one of Turkey's most important development priorities. Today, Turkey's economy is mainly dependent on oil, natural gas, coal, and electricity. Turkey's energy production meets only a part of its total energy consumption and thereby is an energy-importing country. On the other hand, Turkey has a large potential for renewable energies. The most important renewable sources for Turkey's energy sector are wind, biomass, hydro, solar and geothermal. Renewable energy sources respond to the process of the trio of energy, economy, and environment because, as a local source it has many positive effects on employment and provides momentum to the economy of the country. Turkey would have to commit to the development and implementation of renewable energy technologies and energy conservation. The implementation of renewable energy technologies would reduce the current national and global environmental problems as well as national energy insecurity associated with the production and use of fossil energies. Thus, the aim of this article is to present the energy situation and potential of the renewable energy sources in Turkey as well as associate these factors with the economy and business priorities.Article Citation - WoS: 24Citation - Scopus: 28Chemometric Approach To Simultaneous Chromatographic Determination of Paracetamol and Chlorzoxazone in Tablets and Spiked Human Plasma(Taylor & Francis inc, 2006) Ozdemir, A; Aksoy, H; Baleanu, D; Dinç, ENew chemometric approaches were introduced into the high performance liquid chromatographic (HPLC) determination of chlorzoxazone (CZX) and paracetamol (PAR) in the tablets and spiked human plasma. These chemometric approaches contain the application of classical least squares (CLS), principle component regression (PCR), and partial least squares (PLS) calibrations to the multiwavelength HPLC peak area obtained by plotting the chromatograms at the five wavelengths. The multichromatograms were obtained by using the photodiode array detector at 225 (A), 240 (B), 255 (C), 270 (D), and 285 (E) nm. The algorithms of CLS, PCR, and PLS were applied to the multichromatogram data to construct the HPLC-CLS, HPLC-PCR, and HPLC-PLS calibrations. A mixture of acetonitrile and 0.1 M ammonium carbonate (60:40, v/v) on a Waters Symmetry (R) trademark C18 Column 5 mu m 4.6 x 250 mm at a flow rate of 0.8 mL/min was used as a mobile phase to separate and determine CZX and PAR in samples. Hydrochlorothiazide (IS) was used as an internal standard in this chromatographic separation. The HPLC chemometric calibrations were successfully applied to the quantitative analysis of the investigated drugs in commercial pharmaceutical preparation and spiked human plasma samples with high precision and accuracy.