Theoretical and Numerical Analysis of Fractal Fractional Model of Tumor-Immune Interaction With Two Different Kernels

Abstract

Fractal fractional operators in Caputo and Caputo-Fabrizio sense are being used in this manuscript to explore the interaction between the immune system and cancer cells. The tumour-immune model has been investigated numerically and theoretically by the singular and nonsingular fractal fractional operators. Via fixed point theorems, the existence and uniqueness of the model under the Caputo fractal fractional operator have been demonstrated. Using the fixed point theory, the existence of a unique solution has been derived under the Caputo-Fabrizio case. Through nonlinear analysis, the Ulam-Hyres stability of the model has been derived. For the singular and nonsingular fractal fractional operators, numerical results have been developed by Lagrangian-piece wise interpolation. We simulate the numerical results for the various sets of fractional and fractal orders to describe the relationship between immune and cancer cells under the novel operators with two different kernels. We compared the dynamics of the tumor-immune model using a power law and an exponential-decay kernel to explore that the nonsingular fractal fractional operator provides better dynamics for the considered model. (C) 2021 THE AUTHORS. Published by Elsevier BV on behalf of Faculty of Engineering, Alexandria University