One-Dimension Continuous Wavelet Resolution for the Simultaneous Analysis of Binary Mixture of Benazepril and Hydrochlorothiazide in Tablets Using Spectrophotometric Absorbance Data

Abstract

One-dimensional continuous wavelets transform (CWT) followed by a zero-crossing technique were applied to the quantitative resolution of a binary mixture of benazepril (BE) and hydrochlorothiazide (HCT) in two commercial tablet formulations. UV-spectra in the range of 210.1-300.0 nm, were recorded and transferred as vectors having 900 components into MATLAB 6.5. The analyzed signals corresponding to the above vectors were subjected to three CWT families, namely, Mexican (MEX), Haar (HA) and Daubechies3 (DAUB3) wavelets. For these three families a detailed analysis procedure was performed and we retained only those parameters creating many zero-crossing points for transformed signals. At locations where the wavelet transform of one component vanishes, the value of the mixture's transformed signal is due only to the other component. This allows rapid approximate determination of the concentrations. The above three wavelet bases provided reliable results of the analysis of the mixtures containing BE and HCT in two pharmaceutical tablet formulations.