Application of Haar and Mexican Hat Wavelets To Double Divisor-Ratio Spectra for the Multicomponent Determination of Ascorbic Acid, Acetylsalicylic Acid and Paracetamol in Effervescent Tablets

Abstract

Simultaneous determination of ascorbic acid (AA), acetylsalicylic acid (ASP) and paracetamol (PAR) in their synthetic mixtures and effervescent tablets were performed by Haar and Mexican continuous wavelet transforms (HAAR-CWT and MEXH-CWT, respectively) together with double divisor technique. The signal processing methods are based on the application of HAAR-CWT and MEXH-CWT to the double divisor-ratio spectra (DDRS). These spectra were obtained by dividing the absorption spectra of pure compound and its ternary mixtures by a double-divisor or standard spectrum corresponding to a mixture of two compounds in ternary mixture. A combined use of HAAR-CWT and MEXH-CWT with double divisor-ratio spectra (DDRS) was denoted by DDRS-HAAR CWT and DDRS-MEXH CWT. To check the ability or applicability of the developed DDRS-CWT methods, the double divisor-ratio spectra-derivative spectrophotometric (DDRS-DS) method, as a comparison method, was applied to the above mentioned samples containing AA, ASP and PAR and satisfactory results were obtained.