PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12416/8650

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Spectrophotometric multicomponent analysis of a mixture of metamizol, acetaminophen and caffeine in pharmaceutical formulations by two chemometric techniques
(Pergamon-elsevier Science Ltd, 2001) Dinç, E; Baleanu, Dumitru; Baleanu, D; Onur, F; 56389
Inverse least squares (ILS) and factor-based (principal component analysis (PCA)) techniques were proposed for the spectrophotometric multicomponent analysis of a ternary mixture consisting of metamizol, acetaminophen and caffeine, without prior separation. In these chemometric techniques, the measurements of the absorbance values were realized in the spectral range from 225 to 285 nm in the intervals of Delta lambda = 5 nm at the 13 wavelengths in the zero-order spectra of the different ternary mixtures of these active ingredients in 0.1 M HCl. The prepared calibrations of both techniques using the absorbance data and concentration matrix data sets were used to predict the concentration of the unknown concentrations of metamizol acetaminophen and caffeine in their ternary mixture. The 'MAPLE V' software was used for the numerical calculations, Mean recoveries and relative standard deviations for ILS and PCA techniques were found to be 99.8 and 1.68%, 99.9 and 1,66% for caffeine, 99.8 and 1.84%, 100.4 and 2.85% for metamizol, and 99.7 and 1.04%, 99.6 and 1.34/ for acetaminophen, respectively, for the first and second techniques. The techniques were successfully applied to two pharmaceutical formulations marketed in Turkey and results were compared with a new high-performance liquid chromatography method. (C) 2001 Elsevier Science B.V. All rights reserved.
Two new spectrophotometric approaches to the multicomponent analysis of the acetaminophen and caffeine in tablets by classical least-squares and principal component regression techniques
(Elsevier Science Sa, 2002) Dinç, E; Baleanu, Dumitru; Baleanu, D; 56389
Classical least-squares (CLS) and principal. component regression (PCR) techniques were proposed for the simultaneous analysis of tablets containing acetaminophen and caffeine without using a chemical separation procedure. The chemometric calibrations were prepared by measuring the absorbances values at the 15 wavelengths in the spectral region 215-285 nm and by using a training set of the mixtures of both drugs in 0.1 M HCl. The obtained chemometric calibrations were used for the estimation of acetaminophen and caffeine in samples. The numerical calculations were performed with the 'MAPLE V' software. By applying two techniques to synthetic mixtures, the mean recoveries and the relative standard deviations in the CLS and PCR techniques were found as 99.5 and 1.29, 99.7 and 1.00% for acetaminophen and 99.9 and 1.92, 100.0 and 1.178% for caffeine, respectively. Our results were compared with those obtained previously by one of us considering HPLC method as a reference method. These two methods were successfully applied to a pharmaceutical tablet formulation of two drugs. (C) 2002 Elsevier Science S.A. All rights reserved.
Spectrophotometric quantitative determination of cilazapril and hydrochlorothiazide in tablets by chemometric methods
(Pergamon-elsevier Science Ltd, 2002) Dinç, E; Baleanu, Dumitru; Baleanu, D; 56389
Four chemometric methods were applied to simultaneous determination of cilazapril and hydrochlorothiazide in tablets. Classical least-square (CLS), inverse least-square (ILS), principal component regression (PCR) and partial least-squares (PLS) methods do not need any priori graphical treatment of the overlapping spectra of two drugs in a mixture. For all chemometric calibrations a concentration set of the random mixture consisting of the two drugs in 0.1 M HCl and methanol (1:1) was prepared. The absorbance data in the UV-Vis spectra were measured for the 15 wavelength points (from 222 to 276 nm) in the spectral region 210-290 nm considering the intervals of Deltalambda = 4 nm. The calibration of the investigated methods involves only absorbance and concentration data matrices. The developed calibrations were tested for the synthetic mixtures consisting of two drugs and using the Maple V software the chemometric, calculations were performed. The results of the methods were compared each other as well as with HPLC method and a good agreement was found. (C) 2002 Elsevier Science B.V. All rights reserved.
A zero-crossing technique for the multidetermination of thiamine HCl and pyridoxine HCl in their mixture by using one-dimensional wavelet transform
(Elsevier, 2003) Dinç, E; Baleanu, Dumitru; Baleanu, D; 56389
A new zero-crossing technique based on one-dimensional wavelet transform (WT) was developed and applied on a commercial vitamin product and binary mixtures containing thiamine HCl and pyridoxine HCl in the presence of the interference of the analysed signals. We selected from the data of the UV-Vis absorption spectra a signal consisting of 1150 points corresponding to the concentration range 8-32 mg/ml for both vitamins and we subjected it to one-dimensional continuous WT Mexican (MEXICAN) and Meyer (MEYER). Since the peaks of the transformed signals were bigger than original ones a zero crossing technique was applied to obtain the regression equations. The validity of Beer-Lambert law was assumed for the transformed signals. An appropriate scale setting was choosing to obtain an alternative calibration for each method. The basic concepts about wavelet method were briefly explained and MATLAB 6.5 software was used for one-dimensional wavelet analysis, The obtained results were successfully compared among each other and with those obtained by other literature methods. The developed method is rapid, easy to apply. not expensive and suitable for analysing of the overlapping signals of compounds in their mixtures without any chemical pre-treatment. (C) 2003 Elsevier Science B.V. All rights reserved.
Multidetermination of thiamine HC1 and pyridoxine HC1 in their mixture using continuous daubechies and biorthogonal wavelet analysis
(Elsevier Science Bv, 2003) Dinç, E; Baleanu, Dumitru; Baleanu, D; 56389
A new graphical method based on the one-dimensional wavelet transform (WT) was proposed and tested on mixture of thiamine hydrochloride (THI) and pyridoxine hydrochloride (PYR) in the presence of strongly overlapping signals. We selected from the data of the UV-VIS absorption spectra a signal consisting of 1150 points corresponding to the concentration range 8-32 mg ml(-1) for each vitamin and we subjected it to Daubechies8 (DAUB8) and Biorthogonal6.8 (BIOR6.8) wavelet transforms. Since the peaks of the transformed signals were bigger than original ones a zero crossing method was applied to obtain the calibration graphs. In addition, the validity of Beer-Lambert law was assumed for the transformed signals. An appropriate scale setting was choosing to obtain an alternative calibration for each method. MATLAB 6.5 software was used for one-dimensional wavelet analysis and the basic concepts about wavelet method were given. The obtained results were successfully compared among each other as well as with those obtained by other literature methods. The method developed in this paper is rapid, easy to apply, not expensive and it is suitable for analyzing of the overlapping signals of compounds in their mixtures without any chemical pre-treatment. (C) 2002 Elsevier Science B.V. All rights reserved.
Comparative analysis on wavelet-based detection of finite duration low-amplitude signals related to ventricular late potentials
(Iop Publishing Ltd, 2004) Mousa, A; Yilmaz, A
Ventricular late potentials (VLPs) are considered as a noninvasive marker of patients with myocardial infarction, who are prone to the development of ventricular tachycardia. This paper investigates the effects of variations in physical properties of myocardial infarcts in terms of their effects on the parametric variations in VLP analysis. A sufficiently large set of signals underlining the behavior of physical parameters was employed to represent the effect of physical size, position, orientation and type of infarct. The approximated signals are variations from real electrocardiography signals by adding potentials representing late potentials based on duration, frequency, amplitude and position. The aim is not to exactly model VLP but rather to generate an approximate set of signals to examine the performance of the standard methods for different possibilities in infarct dynamics. We investigate some of the detection approaches together with their related assumptions, and try to pinpoint the drawbacks and inaccuracies of these methods and also their assumptions. The three widely accepted criteria-QRS duration, root-mean-square and duration of the signal at the end of QRS for VLP detection-were used in the investigation. Results from the application of these parameters to the set of signals are presented. In addition we investigate the physical nature of an infarct and list a number of possible reasons that might be the cause of a low success rate for the detection of additive potentials. To improve the performance of the common methods, two more wavelet transform parameters are added to those of the standard methods. The method derived from this analysis is presented as an alternative means for the detection of late signals named as delayed potentials, a more general class that includes VLP as a subset.
Modified theory of physical optics
(Optica Publishing Group, 2004) Umul, YZ; Umul, Yusuf Ziya; 42699
A new procedure for calculating the scattered fields from a perfectly conducting body is introduced. The method is defined by considering three assumptions. The reflection angle is taken as a function of integral variables, a new unit vector, dividing the angle between incident and reflected rays into two equal parts is evaluated and the perfectly conducting (PEC) surface is considered with the aperture part, together. This integral is named as Modified Theory of Physical Optics (MTPO) integral. The method is applied to the reflection and edge diffraction from a perfectly conducting half plane problem. The reflected, reflected diffracted, incident and incident diffracted fields are evaluated by stationary phase method and edge point technique, asymptotically. MTPO integral is compared with the exact solution and PO integral for the problem of scattering from a perfectly conducting half plane, numerically. It is observed that MTPO integral gives the total field that agrees with the exact solution and the result is more reliable than that of classical PO integral. (C) 2004 Optical Society of America.
Analysis of reciprocity of cos-Gaussian and cosh-Gaussian laser beams in a turbulent atmosphere
(Optical Soc Amer, 2004) Eyyuboglu, HT; Baykal, Y; 7688; 7812
In a turbulent atmosphere, starting with a cos-Gaussian excitation at the source plane, the average intensity profile at the receiver plane is formulated. This average intensity profile is evaluated against the variations of link lengths, turbulence levels, two frequently used free-space optics wavelengths, and beam displacement parameters. We show that a cos-Gaussian beam, following a natural diffraction, is eventually transformed into a cosh-Gaussian beam. Combining our earlier results with the current findings, we conclude that cos-Gaussian and cosh-Gaussian beams act in a reciprocal manner after propagation in turbulence. The rates (paces) of conversion in the two directions are not the same. Although the conversion of cos-Gaussian beams to cosh-Gaussian beams can happen over a wide range of turbulence levels (low to moderate to high), the conversion of cosh-Gaussian beams to cos-Gaussian beams is pronounced under relatively stronger turbulence conditions. Source and propagation parameters that affect this reciprocity have been analyzed. (C) 2004 Optical Society of America.
Soccer Causes Degenerative Changes in the Cervical Spine
(Springer, 2004) Kartal, A; Yildiran, I; Senköylü, A; Korkusuz, F
Background. Radiological changes and degeneration of the cervical spine have been previously described in soccer players. The onset of such changes was 10-20 years earlier than that of the normal population. The aim of this study was to assess these early degenerative changes in amateur active and veteran soccer players in a cross-sectional descriptive study using biomechanical, radiological, and magnetic resonance measures. Methods. The subjects were active (<30 years; n=15) and veteran (>30 years; n=15) male amateur soccer players, and their age-matched controls (n=13 and n=15). Biomechanical measurements were made on a cervical dynamometer. Dynamic radiological and magnetic resonance findings were also obtained and evaluated. Results. The normalized mean extension moment was higher in the active soccer players, but the mean range of motion was lower. Degenerative changes were prominent in veteran players, and the sagittal diameter of their spinal canal at C2 to C6 was lower when compared to active players and controls. Magnetic resonance findings of degeneration were more prominent in soccer players when compared to their age-matched controls. Conclusion. A tendency towards early degenerative changes exists in soccer players most probably due to high- and/or low-impact recurrent trauma to the cervical spine caused by heading the ball.
Correlation and structure functions of Hermite-sinusoidal-Gaussian laser beams in a turbulent atmosphere
(Optical Soc Amer, 2004) Baykal, Y
To study the performance of atmospheric optical links by using Hermite-sinusoidal-Gaussian laser beam sources, we derive the log-amplitude and the phase correlation and structure functions of such beams in a turbulent atmosphere. Our formulations correctly reduce to the known higher-order mode correlation and structure functions, which in turn reduce to the fundamental-mode (TEM00-mode) results. Several special cases of our formulation are presented, among which the case involving Hermite-cosh-Gaussian dependence is especially noted, since this case is of interest to us owing to the nature of cosh dependence exhibiting the concentration of the energy in the outer lobes of the beam. (C) 2004 Optical Society of America.
Control of trichloroethylene emissions from sparging systems by horizontal bio- and chemo-barriers
(Selper Ltd, Publications Div, 2005) Tezel, U; Demirer, GN; Uludag-Demirer, S
The scope of this study was to develop a continuous system to clean-up a trichloroethylene (TCE) contaminated gas stream, where biotic and abiotic removal mechanisms are undertaken sequentially simulating the horizontal bio- and chemo-barriers proposed for the in-situ remediation of the contaminated sites. The bio- and chemo-barriers were simulated by using glass columns packed with granular anaerobic mixed culture and Fe(0) filings, respectively. The effect of gas residence time, which is adjusted by the gas flowrate, on the TCE removal efficiency of the reactor system was investigated. TCE removal efficiency of over 90% was achieved at gas residence times above 1hr. Furthermore, the effluent of reactor system contained only ethane and ethylene, which are non-toxic by-products of TCE reduction reactions, along with trace amounts of TCE.
Modified theory of physical optics approach to wedge diffraction problems
(Optica Publishing Group, 2005) Umul, YZ; Umul, Yusuf Ziya; 42699
The problem of diffraction from a perfectly conducting wedge is examined with the modified theory of physical optics (MTPO). The exact wedge diffraction coefficient is compared with the asymptotic edge waves of MTPO integral and related surface currents are evaluated. The scattered electric fields are expressed by using these current components. The total, incident and reflected diffracted fields are compared with the exact series solution of the wedge problem, numerically. (C) 2005 Optical Society of America.
Average intensity and spreading of cosh-Gaussian laser beams in the turbulent atmosphere
(Optical Soc Amer, 2005) Eyyuboglu, HT; Baykal, Y; 7688; 7812
The average intensity and spreading of cosh-Gaussian laser beams in the turbulent atmosphere are examined. Our research is based principally on formulating the average-intensity profile at the receiver plane for cosh-Gaussian excitation. The limiting cases of our formulation for the average intensity are found to reduce correctly to the existing Gaussian beam wave result in turbulence and the cosh-Gaussian beam result in free space (in the absence of turbulence). The average intensity and the broadening of the cosh-Gaussian beam wave after it propagates in the turbulent atmosphere are numerically evaluated versus source size, beam displacement, link length, structure constant, and two wavelengths of 0.85 and 1.55 mum, which are most widely used in currently employed free-space-optical links. Results indicate that in turbulence the beam is widened beyond its free-space diffraction values. At the receiver plane, analogous to the case of free space, this diffraction eventually leads to transformation of the cosh-Gaussian beam into an oscillatory average-intensity profile with a Gaussian envelope. (C) 2005 Optical Society of America.
Diffraction by a black half plane: Modified theory of physical optics approach
(Optical Soc Amer, 2005) Umul, YZ; Umul, Yusuf Ziya; 42699
The scattered fields from a black half plane which absorbs all the incoming electromagnetic energy are evaluated by defining a new modified theory of physical optics surface current. This current eliminates the reflected fields, coming from the first stationary point of the reflection integral and only creates a reflected diffracted field. The incident scattered fields are found from the same integral, written for the perfectly conducting half plane. The scattered fields are evaluated by using the stationary phase method and edge point technique. The evaluated fields are plotted numerically. (c) 2005 Optical Society of America.
An application of derivative and continuous wavelet transforms to the overlapping ratio spectra for the quantitative multiresolution of a ternary mixture of paracetamol, acetylsalicylic acid and caffeine in tablets
(Elsevier Science Bv, 2005) Dinç, E; Baleanu, Dumitru; Özdemir, A; Baleanu, D; 56389
Quantitative multi resolution of tablets and ternary mixtures of paracetamol (PAR), acetylsalicylic acid (ASP) and caffeine (CAF) having strongly overlapping spectra was accomplished by two graphical transform methods as ratio spectra first derivative-zero crossing and ratio spectra-continuous wavelet transform-zero crossing (ratio spectra CWT-zero crossing) methods. In this study, ratio spectra derivative-zero crossing and ratio spectra CWT-zero crossing methods are based on the use of transformed signals of the ratio spectra and their calibration graphs were obtained by measuring the dA/dlambda and CWT amplitudes of the ratio spectra corresponding to zero crossing points. For the comparison purpose. PLS calibration method was applied to predict the content of the same mixtures containing the subject active Compounds. The obtained calibrations were tested by using the synthetic mixtures and standard addition technique and they applied to the simultaneous determination of PAR, ASP and CAF in commercial pharmaceutical preparation. The obtained results were statistically compared with each other as well as those obtained by HPLC method and they showed good agreement. (C) 2004 Published by Elsevier B.V.
Comparative study of the continuous wavelet transform, derivative and partial least squares methods applied to the overlapping spectra for the simultaneous quantitative resolution of ascorbic acid and acetylsalicylic acid in effervescent tablets
(Elsevier Science Bv, 2005) Dinç, E; Baleanu, Dumitru; Ozdemir, A; Baleanu, D; 56389
The simultaneous spectrophotometric determination of ascorbic acid (AA) and acetylsalicylic acid (ASA) in effervescent tablets in the presence of the overlapping spectra was accomplished by the continuous wavelet transform (CWT), derivative spectrophotometry (DS) and partial least squares (PLS) approaches without using any chemical pre-treatment. CWT and DS calibration equations for AA and ASA were obtained by measuring the CWT and DS amplitudes corresponding to zero-crossing points of spectra obtained by plotting continuous wavelet coefficients and first-derivative absorbance values versus the wavelengths, respectively. The PLS calibration was constructed by using the concentration set and its full absorbance data consisting of 850 points from 220 to 305 urn in the range of 210-310 nun. These three methods were tested by analyzing the synthetic mixtures of the above drugs and they were applied to the real samples containing two commercial pharmaceutical preparations of subjected drugs. A comparative study was carried out by using the experimental results obtained from three analytical methodologies and precise and accurate results were obtained. (c) 2004 Published by Elsevier B.V.
Hermite-sine-Gaussian and Hermite-sinh-Gaussian laser beams in turbulent atmosphere
(Optical Soc Amer, 2005) Eyyuboglu, HT; Baykal, Y; 7688; 7812
Hermite-sine-Gaussian and Hermite-sinh-Gaussian laser beam intensities in a turbulent atmosphere are investigated. The received intensity is formulated by applying the extended Huygens-Fresnel principle to generalized Hermite-hyperbolic-Gaussian and Hermite-sinusoidal-Gaussian beam incidences. From this result, the association to different types of Hermite-hyperbolic-Gaussian and Hermite-sinusoidal-Gaussian beams are defined. The average receiver intensity expressions for Hermite-sine-Gaussian and Hermite-sinh-Gaussian laser beams are evaluated and plotted against the variations in source parameters and propagation conditions. It is observed that the propagation of Hermite-sine-Gaussian and Hermite-sinh-Gaussian laser beams in turbulence have many similarities to their counterparts, Hermite-cosine-Gaussian and Hermite-cosh-Gaussian laser beams, that are examined earlier. It is further observed that under certain conditions the main features of the previously established reciprocity concept between cosine-Gaussian and cosh-Gaussian beams are mostly applicable to Hermite-sine-Gaussian and Hermite-sinh-Gaussian laser beams. (c) 2005 Optical Society of America.
Hermite-cosine-Gaussian laser beam and its propagation characteristics in turbulent atmosphere
(Optical Soc Amer, 2005) Eyyuboglu, HT; 7688
Hermite-cosine-Gaussian (HcosG) laser beams are studied. The source plane intensity of the HcosG beam is introduced and its dependence on the source parameters is examined. By application of the Fresnel diffraction integral, the average receiver intensity of HcosG beam is formulated for the case of propagation in turbulent atmosphere. The average receiver intensity is seen to reduce appropriately to various special cases. When traveling in turbulence, the HcosG beam initially experiences the merging of neighboring beam lobes, and then a TEM-type cosh-Gaussian beam is formed, temporarily leading to a plain cosh-Gaussian beam. Eventually a pure Gaussian beam results. The numerical evaluation of the normalized beam size along the propagation axis at selected mode indices indicates that relative spreading of higher-order HcosG beam modes is less than that of the lower-order counterparts. Consequently, it is possible at some propagation distances to capture more power by using higher-mode-indexed HcosG beams. (C) 2005 Optical Society of America.
Simplified uniform theory of diffraction
(Optica Publishing Group, 2005) Umul, YZ; Umul, Yusuf Ziya; 42699
Simple exponential functions that approach zero for reflection and shadow boundaries are considered to cancel the infinite values of diffraction coefficients at these regions. This method is applied to a wedge diffraction coefficient, and the resultant uniform coefficient is compared with the exact diffracted fields numerically. (c) 2005 Optical Society of America.
Log-amplitude and phase fluctuations of higher-order annular laser beams in a turbulent medium
(Optical Soc Amer, 2005) Baykal, Y; 7812
Log-amplitude and phase-correlation and structure functions of higher-order annular laser beams in a turbulent atmosphere are derived. A higher-order annular beam source is defined as the superposition of two different higher-order Hermite-Gaussian beams. A special case of such an excitation is the annular Gaussian beam in which two beams operate at fundamental modes of different Gaussian beam sizes, yielding a doughnut-shaped (annular) beam when the second beam is subtracted from the first beam. Our formulation utilizes Rytov approximation, which makes it applicable in the weak-turbulence regime, especially for log-amplitude fluctuations. Limiting cases of our formulations correctly match with known higher-order-mode solutions that in turn reduce to the Gaussian-beam-wave (TEM00-mode) results. Our results can be applied to determine the scintillation index and the phase fluctuations in free-space optics links under higher-order annular laser beam excitation. Except for the numerical evaluation of a specific example covering an annular Gaussian beam, the results in general are left in integral form and need to be numerically evaluated in detail to obtain quantitative results. (c) 2005 Optical Society of America.

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